Anti-inflammatory activity of parthenolide-depleted Feverfew (Tanacetum parthenium)
| Autor: | Michael D. Southall, Peter Lyte, Runa Sur, Katharine Martin, Shapiro Stanley S, Frank Liebel |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Keratinocytes Male medicine.drug_class Immunology Anti-Inflammatory Agents Human skin Inflammation Dermatitis Pharmacology Tanacetum parthenium Sesquiterpene lactone Anti-inflammatory Nitric oxide chemistry.chemical_compound Mice Young Adult medicine Animals Humans Pharmacology (medical) Parthenolide Sensitization Cells Cultured chemistry.chemical_classification Plant Extracts Macrophages Middle Aged medicine.anatomical_structure chemistry Erythema Leukocytes Mononuclear Female medicine.symptom Inflammation Mediators Sesquiterpenes |
| Zdroj: | Inflammopharmacology. 17(1) |
| ISSN: | 1568-5608 |
| Popis: | Extracts of Tanacetum parthenium (L.) Sch. Bip., a plant known under the common name "Feverfew", contains the sesquiterpene lactone parthenolide, a potent skin sensitizer. To eliminate the risk of skin sensitization from Feverfew, we developed a parthenolide-depleted extract of Feverfew (PD-Feverfew) and determined its effectiveness as an anti-inflammatory agent. We confirmed that PD-Feverfew was sufficiently depleted of parthenolide since PD-Feverfew did not inhibit TNF-alpha induced-NF-kappaB activity unlike parthenolide containing whole Feverfew. PD-Feverfew directly inhibited the activity of pro-inflammatory enzymes 5-lipoxygenase, phosphodiesterase-3 and phosphodiesterase-4. PD-Feverfew inhibited the release of pro-inflammatory mediators nitric oxide, PGE(2) and TNF-alpha from macrophages and TNF-alpha, IL-2, IFN-gamma and IL-4 from human peripheral blood mononuclear cells. Additionally, PD-Feverfew inhibited TPA-induced release of PGE(2) from human skin equivalents. In vivo, PD-Feverfew inhibited oxazolone-induced dermatitis, and was more potent than whole Feverfew in reducing TPA-induced dermatitis. Finally the efficacy of PD-Feverfew was confirmed clinically by a reduction in erythema in a methyl nicotinate-induced vasodilation model. In conclusion, our results indicate that PD-Feverfew extracts have potent anti-inflammatory activity suggesting that this botanical would be efficacious in relieving inflammation without inducing immune sensitization. |
| Databáze: | OpenAIRE |
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