Effects of a 3-month course of rosuvastatin in patients with systemic lupus erythematosus
| Autor: | Maarten Limper, H. ten Cate, Eelco W. Meesters, J de Ruiter, Hjalmar R. Hansen, E. C. M. van Gorp, M D de Kruif, Ajda T. Rowshani, C. A. Spek, I J ten Berge |
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| Přispěvatelé: | Other departments, Amsterdam institute for Infection and Immunity, Cancer Center Amsterdam, Center of Experimental and Molecular Medicine, Nephrology, Faculteit der Geneeskunde |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Systemic disease Immunology General Biochemistry Genetics and Molecular Biology Rheumatology immune system diseases Informed consent Immunopathology Internal medicine medicine Humans Lupus Erythematosus Systemic Immunology and Allergy Rosuvastatin Rosuvastatin Calcium skin and connective tissue diseases Autoimmune disease Sulfonamides Cross-Over Studies business.industry medicine.disease Lipids Connective tissue disease Fluorobenzenes C-Reactive Protein Pyrimidines Sample size determination sense organs Hydroxymethylglutaryl-CoA Reductase Inhibitors business medicine.drug |
| Zdroj: | Annals of the rheumatic diseases, 68(10). BMJ Publishing Group Annals of the Rheumatic Diseases, 68(10). BMJ Publishing Group |
| ISSN: | 0003-4967 |
| Popis: | Systemic lupus erythematosus (SLE) is associated with a highly increased cardiovascular risk. Statins can reduce this risk, but may possess additional anti-inflammatory effects that are relevant for the treatment of SLE. In a preliminary study, we investigated the effects of a 3-month course of rosuvastatin on lipids and markers of inflammation using a randomised cross-over design. The study was approved by the institutional medical and ethical committee and written informed consent was obtained from all subjects. Based upon a previous, representative study,1 a sample size of 14 patients would be necessary to demonstrate a 25% reduction in C-reactive protein (CRP) levels (power = 80%). A dropout level of 35% (n = 5) was estimated.2 Patients with stable … |
| Databáze: | OpenAIRE |
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