High level of ezrin expression in colorectal cancer tissues is closely related to tumor malignancy
Autor: | Qun Sun, Hong-Jian Wang, Hua Guo, Qiang Zhang, Jin-Shui Zhu |
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Rok vydání: | 2009 |
Předmět: |
Adult
Male Pathology medicine.medical_specialty Colorectal cancer macromolecular substances Malignancy environment and public health Metastasis Ezrin Intestinal mucosa Animals Humans Medicine Neoplasm Invasiveness Intestinal Mucosa Aged Neoplasm Staging Aged 80 and over business.industry Gastroenterology Cancer General Medicine Middle Aged medicine.disease Brief Articles Cytoskeletal Proteins Lymphatic Metastasis Cancer research Immunohistochemistry Adenocarcinoma Female Colorectal Neoplasms business |
Zdroj: | World Journal of Gastroenterology. 15:2016 |
ISSN: | 1007-9327 |
Popis: | AIM: To investigate the ezrin expression in normal colorectal mucosa and colorectal cancer tissues, and study the correlation between ezrin expression in colorectal cancer tissues and tumor invasion and metastasis. METHODS: Eighty paraffin-embedded cancer tissue samples were selected from primary colorectal adenocarcinoma. Twenty-eight patients had well-differentiated, 22 had moderately differentiated and 30 had poorly differentiated adenocarcinoma. Forty-five patients and 35 patients had lymph node metastasis. Forty-five patients were of Dukes A to B stage, and 35 were of C to D stage. Another 22 paraffin-embedded tissue blocks of normal colorectal epithelium (> 5 cm away from the edge of the tumor) were selected as the control group. All patients with colorectal cancer were treated surgically and diagnosed histologically, without preoperative chemotherapy or radiotherapy. The immunohistochemistry was used to detect the ezrin expression in paraffin-embedded normal colorectal mucosa tissues and colorectal cancer tissue samples. RESULTS: Ezrin expression in colorectal cancer was significantly higher than in normal colorectal mucosa (75.00% vs 9.09%, P < 0.01), and there was a close relationship between ezrin expression and the degree of tumor differentiation, lymph node metastasis and Dukes stage (88.46% vs 50.00%, P < 0.01; 94.28% vs 51.11%, P < 0.01; 94.28% vs 51.11%, P < 0.01). CONCLUSION: Ezrin expression is obviously higher in colorectal cancer tissues than in normal colorectal mucosa tissues, and the high level of ezrin expression is closely related to the colorectal cancer invasion and metastasis process. |
Databáze: | OpenAIRE |
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