Multiple DNA viruses identified in multimammate mouse (Mastomys natalensis) populations from across regions of sub-Saharan Africa
| Autor: | Nafomon Sogoba, Léonce Kouadio, Kyle Rosenke, Emmanuel Couacy-Hymann, Andrew J. Davison, Fabian H. Leendertz, Bernhard Ehlers, Sébastien Calvignac-Spencer, Michael A. Jarvis, Heinz Feldmann |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
viruses Genome Viral medicine.disease_cause 010603 evolutionary biology 01 natural sciences Genome Virus Host Specificity Rodent Diseases 03 medical and health sciences Viral Envelope Proteins Phylogenetics Virology medicine Animals Antigens Viral Tumor Africa South of the Sahara Herpesviridae Phylogeny 030304 developmental biology Disease Reservoirs 0303 health sciences Polyomavirus Infections Arenavirus biology Phylogenetic tree virus diseases DNA virus General Medicine Herpesviridae Infections biochemical phenomena metabolism and nutrition biology.organism_classification Molecular Typing Lassa virus Mastomys Capsid Proteins Original Article Murinae Polyomavirus |
| Zdroj: | Archives of Virology |
| ISSN: | 1432-8798 0304-8608 |
| Popis: | The multimammate mouse (Mastomys natalensis; M. natalensis) serves as the main reservoir for the zoonotic arenavirus Lassa virus (LASV), and this has led to considerable investigation into the distribution of LASV and other related arenaviruses in this host species. In contrast to the situation with arenaviruses, the presence of other viruses in M. natalensis remains largely unexplored. In this study, herpesviruses and polyomaviruses were identified and partially characterized by PCR methods, sequencing, and phylogenetic analysis. In tissues sampled from M. natalensis populations in Côte d'Ivoire and Mali, six new DNA viruses (four betaherpesviruses, one gammaherpesvirus and one polyomavirus) were identified. Phylogenetic analysis based on glycoprotein B amino acid sequences showed that the herpesviruses clustered with cytomegaloviruses and rhadinoviruses of multiple rodent species. The complete circular genome of the newly identified polyomavirus was amplified by PCR. Amino acid sequence analysis of the large T antigen or VP1 showed that this virus clustered with a known polyomavirus from a house mouse (species Mus musculus polyomavirus 1). These two polyomaviruses form a clade with other rodent polyomaviruses, and the newly identified virus represents the third known polyomavirus of M. natalensis. This study represents the first identification of herpesviruses and the discovery of a novel polyomavirus in M. natalensis. In contrast to arenaviruses, we anticipate that these newly identified viruses represent a low zoonotic risk due to the normally highly restricted specificity of members of these two DNA virus families to their individual mammalian host species. |
| Databáze: | OpenAIRE |
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