Feather segmentation to discriminate between different enrofloxacin treatments in order to monitor off-label use in the poultry sector
| Autor: | Bjorn J.A. Berendsen, Larissa J. M. Jansen, Yvette J. C. Bolck |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.drug_class Cephalosporin Antibiotics 010501 environmental sciences Pharmacology Off-label use 01 natural sciences Biochemistry Mass Spectrometry BU Dierbehandelingsmiddelen Analytical Chemistry BU Veterinary Drugs Antibiotic resistance Ciprofloxacin medicine Enrofloxacin Animals LC-MS/MS Chromatography High Pressure Liquid Poultry Diseases 0105 earth and related environmental sciences VLAG business.industry Drug Administration Routes 010401 analytical chemistry Treatments Analytic Sample Preparation Methods Off-Label Use Antedating biochemical phenomena metabolism and nutrition Poultry farming Feathers 0104 chemical sciences Biotechnology Anti-Bacterial Agents Feather visual_art visual_art.visual_art_medium Female business Chickens medicine.drug Fluoroquinolones |
| Zdroj: | Analytical and Bioanalytical Chemistry 408 (2016) Analytical and Bioanalytical Chemistry, 408, 495-502 |
| ISSN: | 1618-2642 |
| DOI: | 10.1007/s00216-015-9118-z |
| Popis: | Antibiotics are commonly used in the poultry industry to treat bacterial infections. In the combat against bacterial resistance, policies require, besides a reduction of antibiotic usage in humans and animals, an up-to-date farmer registration mentioning all treatments. For enforcement of such policies, tests are needed to antedate administration and to determine the type of treatment so as to prevent off-label use and the supervacaneous use of last-resort antibiotics like cephalosporins and fluoroquinolones. After poultry treatment, high amounts of enrofloxacin and its metabolite ciprofloxacin are deposited in chicken feathers. A method is presented to discriminate different treatments based on differentiating extractable and non-extractable enrofloxacin and ciprofloxacin in chicken feathers. With this approach, we show it is possible to distinguish between a registered therapeutic oral treatment, an off-label spray treatment and an illegal prolonged sub-therapeutic treatment with enrofloxacin. This approach is a new and strong tool in the enforcement of new policies in the fight against off-label and supervacaneous antibiotic use. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|