Effect of augmented glycation in mobilization of plasma free fatty acids in type 2 diabetes mellitus

Autor: Masood Azhar, Swatantra Kumar Jain, Ozair Alam, Kailash Chandra, Vineet Jain, Sayeed Ahmad, Washim Khan
Rok vydání: 2020
Předmět:
Blood Glucose
Male
0301 basic medicine
medicine.medical_specialty
Glycosylation
endocrine system diseases
Endocrinology
Diabetes and Metabolism
India
Fatty Acids
Nonesterified
Pentadecanoic acid
Palmitic acid
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Glycation
Diabetes mellitus
Internal medicine
Internal Medicine
Humans
Medicine
Prospective Studies
030212 general & internal medicine
chemistry.chemical_classification
business.industry
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
Fatty acid
General Medicine
Middle Aged
Prognosis
medicine.disease
Lauric acid
030104 developmental biology
Endocrinology
Diabetes Mellitus
Type 2
chemistry
Case-Control Studies
Female
lipids (amino acids
peptides
and proteins)
Stearic acid
business
Biomarkers
Follow-Up Studies
Zdroj: Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 14:1385-1389
ISSN: 1871-4021
DOI: 10.1016/j.dsx.2020.07.028
Popis: Type 2 Diabetes Mellitus (T2DM) is known to be associated with an increase in total plasma free fatty acid (FFA) concentration. The present study was conducted to determine the changes in plasma fatty acids at different levels of glycation in type 2 diabetes mellitus.The study involved 50 subjects having different levels of glycation (HbA1c 4.9-15.0%) and further categorized in 5 groups [group 1 (HbA1c6%), group 2 (HbA1c 6-7%), group 3 (HbA1c 7.1-9%), group 4 (HbA1c (9.1-12%) and group 5 (HbA1c12%)] with 10 subjects in each group.A total of 19 free fatty acids were detected by gas chromatography-mass spectrometry (GC-MS) analysis in the plasma samples. The levels of lauric acid (C12:0) and stearic acid (C18:0) were significantly raised at an advanced stage of glycation (HbA1c 9.1-15%). Long-chain fatty acids, pentadecanoic acid (C15:0) and palmitic acid (C16:0) levels were elevated in hyperglycemia as compared to normoglycaemic subjects (HbA1c6%). Moreover, levels of mono and polyunsaturated fatty acids, oleic acid (C18:1) and linoleic acid (C18:2, w6) were significantly decreased in patients with increased levels of glycation (HbA1c 6-15%).GC-MS is a novel way to study the plasma fatty acid profiling and findings of this study suggest that monitoring alterations in plasma FFA profile may be of prognostic value.
Databáze: OpenAIRE
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