Effect of pregnenolone-16α-carbonitrile, a microsomal enzyme inducer, on the regenerating rat liver
| Autor: | Garg Bd, Kalman Kovacs, B. Tuchweber, J.D. Khandekar |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Pregnenolone Carbonitrile
medicine.medical_specialty Time Factors Histology medicine.medical_treatment Stimulation Cytoplasmic Granules Endoplasmic Reticulum Internal medicine medicine Animals Hepatectomy Enzyme inducer biology Liver cell Body Weight Organ Size Stimulation Chemical Liver regeneration Liver Regeneration Rats Endocrinology Liver Cytoplasm biology.protein Pregnenolone Microsome Female Anatomy Cell Division Glycogen medicine.drug |
| Zdroj: | Cells Tissues Organs. 91:161-174 |
| ISSN: | 1422-6421 1422-6405 |
| DOI: | 10.1159/000144380 |
| Popis: | PCN, a microsomal enzyme inducer, given orally (10 mg in 1 ml water twice daily for 5 days), increased liver weight and mitotic activity in intact as well as in partially hepatectomized rats. Electron microscopy revealed SER proliferation in the hepatocytes of animals treated with PCN alone. Accumulation of SER membranes was also evident in the liver cell cytoplasm of untreated, partially hepatectomized rats; it was however, more pronounced in the hepatocytes of partially hepatectomized animals given PCN. These results indicate that the steriod has a marked effect on the regeneration rat liver. |
| Databáze: | OpenAIRE |
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