Effects of delta-opioid agonist SNC80 on white matter injury following spinal cord ischemia in normothermic and mildly hypothermic rats
| Autor: | Naoko Kurita, Masahiko Kawaguchi, Toshinori Horiuchi, Mitsutoshi Nakamura, Hitoshi Furuya, Takanori Sakamoto, Satoki Inoue, Noboru Konishi |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Agonist medicine.medical_specialty Mild hypothermia medicine.drug_class Motor Activity Motor function Piperazines Body Temperature Rats Sprague-Dawley Random Allocation Hypothermia Induced Receptors Opioid delta Anesthesiology Animals Medicine Single-Blind Method Injections Spinal Neurons Spinal Cord Ischemia business.industry White Matter Injury Spinal cord ischemia Delta opioid agonist Hindlimb Rats Disease Models Animal Treatment Outcome Anesthesiology and Pain Medicine Anesthesia Benzamides business |
| Zdroj: | Journal of Anesthesia. 22:32-37 |
| ISSN: | 1438-8359 0913-8668 |
| Popis: | Although the delta-opioid agonist SNC80 has been shown to attenuate hind-limb motor function and gray matter injury in normothermic rats subjected to spinal cord ischemia (SCI), its effects on white matter injury remain undetermined. In the present study, we investigated whether SNC80 could attenuate white matter injury in normothermic and mildly hypothermic rats.Forty rats were randomly allocated to one of following five groups: vehicle or SNC80 with 10 min of SCI at 38 degrees C (V-38-10m or SNC-38-10m, respectively), vehicle or SNC80 with 22 min of SCI at 35 degrees C (V-35-22m or SNC-35-22m, respectively), or sham. SNC80 or vehicle was intrathecally administered 15 min before SCI. Forty-eight hours after reperfusion, the white matter injury was evaluated by the extent of vacuolation.The percent area of vacuolation in the ventral white matter was significantly lower in the SNC-38-10m and SNC-35-22m groups compared with that in the V-38-10m and V-35-22m groups, respectively (P0.05).The results indicate that intrathecal treatment with the delta-opioid agonist SNC80 can attenuate the ventral white matter injury following SCI in rats under normothermic and mildly hypothermic conditions. |
| Databáze: | OpenAIRE |
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