Effect of a highly purified hyaluronidase preparation (GL enzyme) on electrocardiographic changes in acute myocardial infarction
| Autor: | A. Henderson, Ronald W.F. Campbell, D.G. Julian |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Myocardial Infarction Hyaluronoglucosaminidase Placebo QRS complex Electrocardiography Random Allocation Double-Blind Method Hyaluronidase Internal medicine medicine Humans cardiovascular diseases Myocardial infarction Adverse effect chemistry.chemical_classification Clinical Trials as Topic medicine.diagnostic_test business.industry General Medicine medicine.disease Hyaluronidase preparation Enzyme chemistry Cardiology business medicine.drug |
| Zdroj: | Lancet (London, England). 1(8277) |
| ISSN: | 0140-6736 |
| Popis: | A highly purified preparation of hyaluronidase (GL enzyme) was given in a double-blind, placebo-controlled, randomised study to 192 consecutive patients within 12 h of suspected myocardial infarction. Compared with those receiving placebo, patients with definite myocardial infarction given GL enzyme had significantly less change in QRS complexes; in those with anterior infarction the development of Q waves was less prominent. At 4 months the overall mortality among those with definite and possible myocardial infarction receiving GL enzyme (6 out of 83 patients, 7.2%) was lower than that in those receiving placebo (11 out of 79, 14%); this difference was not significant. No adverse effects were observed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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