Omentin and chemerin and their association with obesity in women with polycystic ovary syndrome
| Autor: | Remzi Abali, Cem Çelik, Volkan Kucukyalcin, Eda Çelik Güzel, Murat Guzel, Elcin Celik, Murat Yilmaz |
|---|---|
| Přispěvatelé: | Kırşehir Ahi Evran Üniversitesi, Mucur Meslek Yüksekokulu, Bilgisayar Teknolojileri Bölümü |
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Outpatient Clinics Hospital Adolescent Turkey medicine.drug_class Endocrinology Diabetes and Metabolism Down-Regulation Overweight GPI-Linked Proteins Body Mass Index Androgen Hospitals University Young Adult Endocrinology Insulin resistance Lectins insulin resistance Internal medicine Humans Medicine Chemerin Endocrine system Obesity Adiposity omentin biology Waist-Hip Ratio business.industry nutritional and metabolic diseases Obstetrics and Gynecology medicine.disease Control subjects Polycystic ovary Up-Regulation Cross-Sectional Studies polycystic ovary syndrome biology.protein Cytokines Intercellular Signaling Peptides and Proteins Female Chemokines medicine.symptom business chemerin |
| Zdroj: | Gynecological Endocrinology. 30:419-422 |
| ISSN: | 1473-0766 0951-3590 |
| Popis: | WOS: 000336790400005 PubMed ID: 24524360 We aimed to investigate whether overweight/obesity is associated with omentin and chemerin. The study group consisted of 81 women with Polycystic ovarian syndrome (PCOS) (41 lean, BMI25 kg/m(2)) and 61 healthy subjects (31 lean, BMI25 kg/m(2); control group). The clinical, endocrine, metabolic parameters, plasma omentin and chemerin levels were measured in patients and compared to control. In all subjects with PCOS (n = 80), serum chemerin levels were higher compared with those of the controls (n = 58) (7.71 +/- 1.78 ng/mL versus 6.94 +/- 0.82 ng/mL, p = 0.003). However, serum omentin levels were not significantly different between the PCOS subjects and the controls (1.55 +/- 0.43 ng/mL versus 1.69 +/- 0.37 ng/mL, p = 0.056). The mean chemerin concentrations were significantly elevated in the obese PCOS group compared with the obese control subjects (8.98 +/- 1.45 ng/mL versus 7.02 +/- 0.67 ng/mL, p = 0.000) and the nonobese PCOS group compared with the obese control subjects (6.57 +/- 1.17 ng/mL versus 7.02 +/- 0.67 ng/mL, p = 0.000). In conclusion, fat mass seems to be the main determinant factor of increased chemerin and decreased omentin in women with PCOS. Namik Kemal UniversityNamik Kemal University The contribution of all authors and project partners is acknowledged, along with the support of Namik Kemal University. |
| Databáze: | OpenAIRE |
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