Spinal cord stimulation ameliorates detrusor over-activity and visceromotor pain responses in rats with cystitis

Autor: Gamal M. Ghoniem, David A. Ginsberg, Larissa V. Rodriguez, Jih-Chao Yeh, Jackie J. Mao, Huiyi H. Chang
Rok vydání: 2018
Předmět:
electromyography
medicine.medical_treatment
030232 urology & nephrology
urologic and male genital diseases
Rats
Sprague-Dawley
0302 clinical medicine
Cystitis
media_common
Spinal Cord Stimulation
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
Pain Research
Cystometry
Visceral Pain
Urology & Nephrology
neuromodulation
Hyperalgesia
Female
Chronic Pain
medicine.symptom
Muscle Contraction
medicine.drug
Urologic Diseases
medicine.medical_specialty
Cyclophosphamide
Urology
media_common.quotation_subject
Clinical Sciences
Urinary Bladder
Intraperitoneal injection
Urination
Article
03 medical and health sciences
Urethra
medicine
Animals
external urethral sphincter
Electromyography
Urinary Bladder
Overactive
business.industry
Urethral sphincter
Neurosciences
Interstitial Cystitis
Visceral pain
Rats
Urodynamics
Reflex
Sprague-Dawley
Neurology (clinical)
business
Overactive
Zdroj: Neurourology and urodynamics, vol 38, iss 1
ISSN: 0733-2467
DOI: 10.1002/nau.23827
Popis: Author(s): Chang, Huiyi H; Yeh, Jih-Chao; Mao, Jackie; Ginsberg, David A; Ghoniem, Gamal; Rodriguez, Larissa V | Abstract: AimInterstitial cystitis/painful bladder syndrome/(IC/PBS) results in recurring pain in the bladder and surrounding pelvic region caused by abnormal excitability of micturition reflexes. Spinal cord stimulation (SCS) is currently clinically used for the attenuation of neuropathic and visceral pain. The present study examined whether SCS at upper lumbar segments modulates detrusor overactivity and visceral hyperalgesia associated with cystitis in a rat model of cyclophosphamide (CYP)-induced cystitis.MethodsCystitis was induced by intraperitoneal injection of CYP (200 mg/kg) in six adult female Sprague Dawley rats 48 h prior to urodynamic recordings. Another six rats served as-controls with saline injection. Cystometry and the external urethral sphincter (EUS) electromyography during bladder infusion were evaluated under urethane anesthesia. The visceromotor reflexes (VMR) obtained from the external abdominal oblique muscle were quantified during bladder infusion and isotonic bladder distension (IBD), respectively. After baseline recordings were taken, SCS was applied on the dorsal surface of L3 for 25 min. Urodynamic recordings and VMR during bladder infusion and IBD were repeated 2 h after SCS.ResultsCYP resulted in detrusor overactivity, stronger EUS tonic contractions, and increased VMR. SCS significantly reduced non-voiding contractions, prolonged EUS relaxation, and delayed VMR appearance during bladder infusion as well as significantly decreased VMR during IBD in cystitis rats.ConclusionSCS improved bladder function and EUS relaxation during bladder infusion and significantly attenuated visceral nociceptive-related VMR during IBD in cystitis rats. SCS may have therapeutic potential for patients with hyperalgesia and IC/PBS.
Databáze: OpenAIRE
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