[Ag2(aca)2]n and [Ag4(aca)4(NH3)2] (acaH=9-anthracenecarboxylic acid): Synthesis, X-ray crystal structures, antimicrobial and anti-cancer activities

Autor:	Denise A. Egan, Michael Devereux, Robert Curran, Grace Clifford, Joanne Lenehan, Kevin Kavanagh, Bernadette S. Creaven, Vickie McKee, Kevin N. Keane, Malachy McCann
Rok vydání:	2007
Předmět:	Ligand Stereochemistry X-ray Crystal structure Antimicrobial Inorganic Chemistry Crystallography chemistry.chemical_compound chemistry 9-anthracenecarboxylic acid Materials Chemistry Carboxylate Physical and Theoretical Chemistry Cancer cell lines Bimetallic strip
Zdroj:	Inorganic Chemistry Communications. 10:1149-1153
ISSN:	1387-7003
Popis:	[Ag2(9-aca)2]n and [Ag4(9-aca)4(NH3)2] (9-acaH = 9-anthracenecarboxylic acid) have been prepared and structurally characterized. [Ag2(9-aca)2]n consists of polymeric ribbons of linked disilver(I) syn–syn bridged dicarboxylate units. [Ag4(9-aca)4(NH3)2] is tetrameric and centrosymmetric, with two syn–syn bridging carboxylates linked to the bimetallic Ag–Ag core and a further two syn–anti bridged carboxylate ligands in the equatorial plane, being coordinated to one Ag in the bimetallic core and to a second Ag, with the latter also bonded to an NH3 ligand. In vitro studies show that both complexes are extremely cytotoxic against selected human fungal and bacterial pathogens, and each complex also greatly inhibits the growth of two mammalian cancer cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241f5818b5db2f0894c13d011398c529 https://doi.org/10.1016/j.inoche.2007.06.021 Zobrazit plný text záznamu Full Text from ScienceDirect