Chemokine-Cytokine Networks in the Head and Neck Tumor Microenvironment
| Autor: | Sabah Nisar, Geetanjali Sageena, Muzafar A. Macha, Deepika Mishra, Tariq Masoodi, Ajaz A. Bhat, Mohammad Haris, Nissar A. Wani, Parvaiz Yousuf, Sheema Hashem, Rakesh Kumar, Mayank Singh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Chemokine
Stromal cell Angiogenesis QH301-705.5 medicine.medical_treatment chemokines Review Catalysis Metastasis Inorganic Chemistry angiogenesis head and neck squamous cell carcinomas response to therapy medicine metastasis Humans tumor microenvironment Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy immune evasion Tumor microenvironment biology business.industry Organic Chemistry apoptosis Cancer General Medicine medicine.disease Prognosis invasion cytokines Computer Science Applications stomatognathic diseases Chemistry Cytokine Tumor progression Head and Neck Neoplasms Cancer research biology.protein Carcinoma Squamous Cell business Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 4584, p 4584 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Head and neck squamous cell carcinomas (HNSCCs) are aggressive diseases with a dismal patient prognosis. Despite significant advances in treatment modalities, the five-year survival rate in patients with HNSCC has improved marginally and therefore warrants a comprehensive understanding of the HNSCC biology. Alterations in the cellular and non-cellular components of the HNSCC tumor micro-environment (TME) play a critical role in regulating many hallmarks of cancer development including evasion of apoptosis, activation of invasion, metastasis, angiogenesis, response to therapy, immune escape mechanisms, deregulation of energetics, and therefore the development of an overall aggressive HNSCC phenotype. Cytokines and chemokines are small secretory proteins produced by neoplastic or stromal cells, controlling complex and dynamic cell–cell interactions in the TME to regulate many cancer hallmarks. This review summarizes the current understanding of the complex cytokine/chemokine networks in the HNSCC TME, their role in activating diverse signaling pathways and promoting tumor progression, metastasis, and therapeutic resistance development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|