Podophyllotoxin Cytological Effects on the Epidermis in Condyloma Acuminatum
| Autor: | Bonnie Leung, Tyler Enos, Travis Vandergriff |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Epidermis (botany) Overtreatment Vulvar Neoplasms Dermatology General Medicine Condyloma Acuminatum Biology Antineoplastic Agents Phytogenic Pathology and Forensic Medicine Podophyllotoxin Condylomata Acuminata medicine Carcinoma Squamous Cell Humans Female Diagnostic Errors Epidermis medicine.drug |
| Zdroj: | The American Journal of dermatopathology. 44(1) |
| ISSN: | 1533-0311 |
| Popis: | Podophyllotoxin (PPT) is used to treat condylomata acuminata and works by destabilizing microtubules within epithelial cells, leading to mitotic arrest in metaphase. PPT-induced changes to the epidermis can cause histological findings mimicking dysplasia. Here, we present a case of vulvar condyloma acuminatum treated with PPT, showing ballooning degeneration, necrotic keratinocytes, and mitotic figures. PPT-treated skin may resemble dysplasia or squamous cell carcinoma in situ due to dyskeratosis and frequent mitoses; however, the synchronicity of mitotic figures in early phases of mitosis, as well as the absence of cellular pleomorphism and atypical mitotic figures, allows for distinction from malignancy. This case demonstrates the importance of understanding the histological changes caused by PPT to prevent misdiagnosis and potential overtreatment. |
| Databáze: | OpenAIRE |
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