Epidemiological characteristics of a Spanish cohort of patients diagnosed with squamous cell carcinoma of head and neck: distribution of risk factors by tumor location
| Autor: | Marina Pollán, C. Salvador Coloma, Raquel Seijas-Tamayo, Javier Martinez-Trufero, Elisabeth Pérez-Ruiz, A. Rueda Domínguez, S. Vazquez Estevez, Ricard Mesia, T. Bonfill Abella, Juan J. Cruz-Hernández, S. Vázquez Fernández, Miren Taberna, J.C. Adansa Klain, M. Pastor Borgoñón, E. del Barco Morillo, Javier Fernández-Mateos |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Multivariate analysis Alcohol Drinking Disease 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Epidemiology Humans Medicine 030212 general & internal medicine Aged Aged 80 and over Squamous Cell Carcinoma of Head and Neck business.industry Smoking Head and neck cancer Cancer General Medicine Middle Aged Laryngeal Neoplasm medicine.disease Surgery Oncology Head and Neck Neoplasms Spain 030220 oncology & carcinogenesis Cohort Carcinoma Squamous Cell Female business Cohort study |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1699-3055 1699-048X |
| Popis: | Head and neck cancer is a highly heterogeneous disease comprising a large number of tumors located in the cervicofacial area. This study aimed to determine the epidemiological characteristics of squamous-cell carcinomas of the head and neck in the Spanish population, and the distribution of risk factors based on tumor locations. A cohort of 459 patients (75 oral cavity, 167 oro-/hypopharyngeal and 217 laryngeal cancers) recruited in 19 hospitals participating in the Spanish head and neck cancer cooperative group were included over 3 years (2012–2014). Epidemiological parameters and risk factors were obtained from a self-administered questionnaire, and tumor characteristics were obtained from clinical records. Multivariate multinomial logistic regression was used to assess factors associated with tumor location. Most patients were males (88.4 %), smokers (95 %) and drinkers (76.5 %). Relative to laryngeal cancer, pharyngeal cancer and oral cancer were more common in women than men (OR 3.58, p = 0.003 and 4.33, p = 0.001, respectively); pharyngeal cancer was more associated with rural environment (OR 1.81, p = 0.007) and weekly alcohol intake (10–140 g: OR 2.53, p = 0.012; 141–280 g: OR 2.47, p = 0.023; >280 g: OR 3.20, p = 0.001) and less associated with pack-years of smoking (21–40 packs: OR 0.46, p = 0.045; 41–70 packs: OR 0.43, p = 0.023; ≥71 packs: OR 3.20, p = 0.015). The distribution of these tumors differs between the sexes, with a higher proportion of oral cavity and pharyngeal tumors in women than in men. Oro-/hypopharyngeal cancers were more strongly associated with rural areas and with alcohol consumption, although less strongly associated with smoking than laryngeal tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink