Characteristics of blood tests in patients with acute cerebral infarction who developed symptomatic intracranial hemorrhage after intravenous administration of recombinant tissue plasminogen activator
| Autor: | Jang Hee Lee, Young Hwan Lee, Pil Cho Choi, Sang Kuk Han, Dong Hyuk Shin, Ji Ung Na, Sang O Park, Chungjo Lee |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Hematologic tests 030204 cardiovascular system & hematology Emergency Nursing Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Statistical significance Internal medicine Lactate dehydrogenase medicine Coagulopathy Blood test Platelet medicine.diagnostic_test business.industry Cerebral infarction 030208 emergency & critical care medicine Retrospective cohort study Emergency department medicine.disease Thrombolytic therapy chemistry Intracranial hemorrhages Emergency Medicine Original Article business |
| Zdroj: | Clinical and Experimental Emergency Medicine |
| ISSN: | 2383-4625 |
| Popis: | OBJECTIVE Patients suspected as having acute ischemic stroke usually undergo blood tests, including coagulation-related indexes, because thrombocytopenia and coagulopathy are contraindications for recombinant tissue plasminogen activator (rtPA) administration. We aimed to identify blood test indexes associated with symptomatic intracranial hemorrhage (sICH) in patients with acute ischemic stroke who received intravenous rtPA. METHODS This retrospective observational study included patients diagnosed with acute ischemic stroke who were treated with intravenous rtPA at the emergency department of a tertiary hospital in Seoul between February 2008 and January 2018. Blood test indexes were compared between the sICH and non-sICH groups. Logistic regression and receiver-operating characteristic curve analyses were performed. RESULTS In this study, 375 patients were finally included. Of 375 patients, 42 (11.2%) showed new intracranial hemorrhage on follow-up brain computed tomography, of whom 14 (3.73%) had sICH. Platelet count, aspartate aminotransferase and lactate dehydrogenase levels were significantly different between the sICH and non-sICH groups, and platelet count showed statistical significance in the regression analysis. Significantly lower platelet counts were observed in the sICH group than in the non-sICH group (174,500 vs. 228,000/mm3, P=0.020). The best cutoff platelet count was 195,000/mm3, and patients with platelet counts of |
| Databáze: | OpenAIRE |
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