The diagnostic value of TROP-2, SLP-2 and CD56 expression in papillary thyroid carcinoma

Autor: Lijuan Zhang, He Shi, Zhixiao Wang, Chengzhou Zhang, Xiaoyun Liu, Huanhuan Chen, Xueyang Yang, Dai Cui, Yifang Hu
Rok vydání: 2018
Předmět:
Zdroj: European Archives of Oto-Rhino-Laryngology. 275:2127-2134
ISSN: 1434-4726
0937-4477
DOI: 10.1007/s00405-018-5045-x
Popis: The study aimed to explore some novel diagnostic biomarkers for papillary thyroid carcinoma (PTC) by identifying the different expression of TROP-2, SLP-2 and CD56 in benign and malignant thyroid lesions. We evaluated the mRNA expressions of TROP-2 and SLP-2 in fine needle aspirates (FNAs) which contained 10 PTCs and 10 benign follicular adenomas (FAs) using quantitative real-time PCR (qRT-PCR). Immunohistochemical (IHC) staining of TROP-2, SLP-2 and CD56 was also performed on postoperative samples of 30 PTCs and 29 FAs. Membranous or cytoplasmic staining in > 10% of cells was considered as positive. Diagnostic sensitivity, specificity, positive predictive value, negative predictive value (NPV) and diagnostic accuracy of these three biomarkers were carried out. We further analyzed the associations between the clinical features and the expressions of markers in PTCs. The mRNA expressions of both TROP-2 and SLP-2 were increased substantially in PTCs in comparison with those in FAs (P
Databáze: OpenAIRE
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