In vitro activity and in vivo efficacy of tigecycline alone and in combination with daptomycin and rifampin against Gram-positive cocci isolated from surgical wound infection
| Autor: | Carmela Silvestri, D. Arzeni, Mauro Provinciali, Fiorenza Orlando, Andrea Giacometti, Silvia Staffolani, Giulia Ganzetti, A. M. Offidani, Lucia Brescini, Roberto Ghiselli, Oscar Cirioni, Mario Guerrieri, Oriana Simonetti |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Microbiology (medical) medicine.drug_class Antibiotics Minocycline Microbial Sensitivity Tests Tigecycline Pharmacology Enterococcus faecalis Microbiology Mice Daptomycin polycyclic compounds medicine Animals Surgical Wound Infection Gram-Positive Bacterial Infections Mice Inbred BALB C biology Teicoplanin business.industry Drug Synergism Surgical wound General Medicine biochemical phenomena metabolism and nutrition biology.organism_classification Antimicrobial Anti-Bacterial Agents Gram-Positive Cocci Disease Models Animal Treatment Outcome Infectious Diseases Drug Therapy Combination Rifampin business Rifampicin medicine.drug |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 31:1759-1764 |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/s10096-011-1498-1 |
| Popis: | The aim of this work was to determine the in vitro activity of tigecycline and its bactericidal effect for a large number of Gram-positive cocci, as well as to investigate its in vitro interaction with six clinically used antibiotics. In vivo, a wound model was established through the panniculus carnosus of BALB/c mice, and then inoculated with 5 × 10(7) colony-forming units (CFU) of Staphylococcus aureus or Enterococcus faecalis. For each bacterial strain, the study included an infected or non-infected group that did not receive any treatment, three groups singly treated with tigecycline, rifampin, and daptomycin, and two groups that received tigecycline treatment plus rifampin or daptomycin. In the in vitro studies, tigecycline, daptomycin, and teicoplanin were active against all of the 48 Gram-positive isolates. The combination of tigecycline with rifampicin and daptomycin was synergistic against S. aureus and Enterococcus spp. In the in vivo studies, all groups treated with single drugs showed statistically significant results compared to the control group. The two groups treated with a combination of drugs showed the highest antimicrobial efficacy. In conclusion, our results suggested a strong activity of tigecycline alone and in combination with other antimicrobial agents against multi-resistant Gram-positive organisms isolated from wound infections. |
| Databáze: | OpenAIRE |
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