Methyl Mercury, Mercuric Chloride, and Silver Lactate Decrease Superoxide Anion Formation and Chemotaxis in Human Polymorphonuclear Leucocytes
| Autor: | Birte Hansen, Margot Martiny Christensen, Jørgen Rungby, Niels Obel, Søren Lyhne Nielsen |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Cell Survival
Neutrophils Health Toxicology and Mutagenesis chemistry.chemical_element In Vitro Techniques Granulocyte Toxicology 030226 pharmacology & pharmacy Chloride 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Superoxides medicine Humans Lactic Acid 030212 general & internal medicine Viability assay Cytotoxicity Superoxide Chemotaxis General Medicine Methylmercury Compounds Lactic acid Mercury (element) N-Formylmethionine Leucyl-Phenylalanine Chemotaxis Leukocyte Microscopy Electron medicine.anatomical_structure chemistry Biochemistry Mercuric Chloride Lactates Tetradecanoylphorbol Acetate medicine.drug |
| Zdroj: | Human & Experimental Toxicology. 12:361-364 |
| ISSN: | 1477-0903 0960-3271 |
| DOI: | 10.1177/096032719301200503 |
| Popis: | Cytotoxic effects of mercuric chloride, methyl mercury, and silver lactate on polymorphonuclear leucocytes have been examined by assaying superoxide anion formation capability and chemotaxis of metal-exposed cells. Both superoxide anion formation and chemotaxis were negatively affected by all three metal compounds. Both bacteriotoxic functions were affected in a dose-dependent fashion, the functional deficits were seen at doses not affecting cell viability. Dose-response curves were remarkably similar for all three compounds. The bacteriotoxic capacity of polymorphonuclear leucocytes may be hampered by mercury and silver. |
| Databáze: | OpenAIRE |
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