Domestic cat allergen and allergic sensitisation in young children
| Autor: | Marjan Kerkhof, Ulrike Gehring, Emma Nordling, Magnus Wickman, G Pershagen, Alet H. Wijga, Chih-Mei Chen, Joachim Heinrich, Mariëlla Giovannangelo, Johan C. de Jongste, Tom Bellander, Catarina Almqvist, Gerard Hoek, Bert Brunekreef, H.-Erich Wichmann |
|---|---|
| Přispěvatelé: | Groningen Research Institute for Asthma and COPD (GRIAC), Pediatrics |
| Rok vydání: | 2006 |
| Předmět: |
Allergy
Pediatrics CHILDHOOD medicine.disease_cause Cohort Studies Allergen Germany Prevalence Medicine Child Netherlands RISK Air Pollutants biology medicine.diagnostic_test BIRTH COHORT Radioallergosorbent test Dust Europe RESPIRATORY SYMPTOMS Air Pollution Indoor Child Preschool Population study PET OWNERSHIP Cohort study medicine.medical_specialty ENDOTOXIN EXPOSURE cat allergen Radioallergosorbent Test children Mite cohort study Hypersensitivity Animals Humans Asthma MITE Sweden business.industry sensitisation Public Health Environmental and Occupational Health Allergens Immunoglobulin E biology.organism_classification medicine.disease allergy IN-HOUSE DUST LIFE Case-Control Studies Cats ASTHMA business Demography Blood sampling |
| Zdroj: | International journal of hygiene and environmental health, 211(3-4), 337-344. ELSEVIER GMBH, URBAN & FISCHER VERLAG International Journal of Hygiene and Environmental Health, 211, 337-344. Urban und Fischer Verlag Jena |
| ISSN: | 1438-4639 |
| Popis: | Studies have presented conflicting associations between cat allergen exposure and sensitisation and atopic disease. We therefore investigated the association between the observed domestic cat allergen level and cat sensitisation in young children in four study populations from three European countries. We recruited children from a nested case-control study, which is composed of four ongoing birth cohorts conducted in three European countries. Children at 2-4 years of age in the four cohorts who were sensitised to cat allergens (n = 106) were compared with 554 non-sensitised children (controls). House dust samples were collected when the children were 5 to 7 years old, and cat allergen levels were measured in ng/g dust and ng/m(2) surface area. In the German study population we found a positive association between domestic cat allergen in house dust and cat sensitisation (OR (CI) = 3.01 (1.16, 7.99)) while in the Swedish study population, we found a negative association (OR (CI) = 0.41 (0.16, 0.98)). No association was found in the Dutch study population (OR (CI) = 0.83 (0.22, 2.93)). Looking into the family history of cat keeping, we found the lowest prevalence of cat sensitisation in children who were cat owners at the age of blood sampling (11%) and the highest prevalence was found in those who have had a cat but not anymore, at the age of blood sampling (41%). The mixed results may be explained by differences in age and avoidance patterns. (C) 2007 Elsevier GmbH. All rights reserved. |
| Databáze: | OpenAIRE |
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