HIV type 1 subtypes among STI patients in Nairobi: a genotypic study based on partial pol gene sequencing
| Autor: | Raphael W. Lihana, Fredrick A. Okoth, Matilu Mwau, Elijah M. Songok, Nancy Lagat, Ernest P. Makokha, Saida Osman, Gabriel Magoma, Samoel Khamadi, Michael Kiptoo, Joyceline Kinyua, Vincent Onyango |
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| Rok vydání: | 2006 |
| Předmět: |
Genotype
Immunology Molecular Sequence Data Human immunodeficiency virus (HIV) Virulence Gene Products pol HIV Infections Biology medicine.disease_cause Virus Virology medicine Humans Risk factor Gene Phylogeny Genetics Genetic diversity virus diseases biology.organism_classification Kenya Infectious Diseases Lentivirus HIV-1 |
| Zdroj: | AIDS research and human retroviruses. 22(11) |
| ISSN: | 0889-2229 |
| Popis: | Circulating strains of human immunodeficiency virus (HIV) exhibit an extraordinary degree of genetic diversity and have been classified on the basis of relationships into distinct lineages called groups, types, subtypes, and subsubtypes. Sexually transmitted infections (STIs) are known to be a risk factor for HIV infection. To establish HIV-1 subtype diversity among STI patients in Nairobi, 140 samples were collected and partial pol gene sequencing done. From the analysis it was established that subtype A1 was the major subtype (64%) followed by D (17%), C (9%), G (1%), and recombinants AD (4%), AC (3%), CRF02()AG (1%), and CRF16()A2D (1%). These results suggest that the HIV-1 epidemic may be evolving toward more virulent and complex subtypes through transmission of complex recombinants due to viral mixing. Any use of ARVs may therefore require initial testing for de novo resistance before commencement of treatment and/or management. |
| Databáze: | OpenAIRE |
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