Decrease in Circulating and Urine Adrenomedullin Concentrations in Stroke-Prone Spontaneously Hypertensive Rats
| Autor: | Junichiro Sakata, Yasushi Koiwaya, Shuji Hirano, Takuroh Imamura, Yuichiro Ishiyama, Takeshi Matsuo, Tanenao Eto, Kazuo Kitamura |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Physiology Urinary system Radioimmunoassay Gene Expression Blood Pressure Vasodilation Urine Rats Inbred WKY Adrenomedullin Heart Rate Rats Inbred SHR Internal medicine Internal Medicine medicine Albuminuria Animals RNA Messenger Stroke Antihypertensive Agents Chemistry Body Weight Age Factors Metabolism Creatine medicine.disease Rats Cerebrovascular Disorders Endocrinology Blood pressure Hypertension Peptides Cardiology and Cardiovascular Medicine |
| Zdroj: | Hypertension Research. 21:23-28 |
| ISSN: | 1348-4214 0916-9636 |
| Popis: | Adrenomedullin (AM) is a peptide with potent vasodilatory and hypotensive properties. Plasma AM levels in rats with experimentally induced hypertension, such as Dahl salt-sensitive rats and two-kidney, one-clip hypertensive rats, are higher than those in normotensive rats. We previously noted, however, that plasma AM levels in spontaneously hypertensive rats (SHR) are similar to those in Wistar-Kyoto rats. To define the role of AM in rats with severe hypertension, we investigated changes in circulating and tissue AM levels in stroke-prone spontaneously hypertensive rats (SHRSP/Izm). The immunoreactive rat AM levels in plasma, urine, and tissue measured with a sensitive radioimmunoassay, and the AM mRNA levels in various tissues in 15-wk-old SHRSP/Izm were compared with those in age-matched Wistar-Kyoto rats (WKY/Izm). The plasma and urinary AM levels in SHRSP/Izm were significantly lower than those in WKY/Izm [plasma AM, 2.14±0.06 (SE) vs. 3.24±0.16fmol/ml, p |
| Databáze: | OpenAIRE |
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