Single prolonged stress alters neural activation in the periacqueductal gray and midline thalamic nuclei during emotional learning and memory
| Autor: | Dayan Knox, Rebecca Della Valle, Negin Mohammadmirzaei |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Stress Disorders
Traumatic Proto-Oncogene Proteins c-jun Cognitive Neuroscience Conditioning Classical education Midline Thalamic Nuclei Sensory system Periaqueductal gray Amygdala Extinction Psychological 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Memory medicine Animals Periaqueductal Gray Fear conditioning Prefrontal cortex Behavior Animal business.industry Research Traumatic stress Fear Extinction (psychology) Rats Disease Models Animal Neuropsychology and Physiological Psychology medicine.anatomical_structure nervous system business Proto-Oncogene Proteins c-fos Neuroscience Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Learn Mem |
| ISSN: | 1549-5485 |
| DOI: | 10.1101/lm.050310.119 |
| Popis: | Clinical and preclinical studies that have examined the neurobiology of persistent fear memory in posttraumatic stress disorder (PTSD) have focused on the medial prefrontal cortex, hippocampus, and amygdala. Sensory systems, the periaqueductal gray (PAG), and midline thalamic nuclei have been implicated in fear and extinction memory, but whether neural activity in these substrates is sensitive to traumatic stress (at baseline or during emotional learning and memory) remains unexplored. To address this, we used the single prolonged stress (SPS) model of traumatic stress. SPS and control rats were either subjected to fear conditioning (CS-fear) or presented with CSs alone (CS-only) during fear conditioning. All rats were then subjected to extinction training and testing. A subset of rats were euthanized after each behavioral stage and c-Fos and c-Jun used to measure neural activation in all substrates. SPS lowered c-Jun levels in the dorsomedial and lateral PAG at baseline, but the elevated c-Jun expression in the PAG during emotional learning and memory. SPS also altered c-Fos expression during fear and extinction learning/memory in midline thalamic nuclei. These findings suggest changes in neural function in the PAG and midline thalamic nuclei could contribute to persistent fear memory induced by traumatic stress. Interestingly, SPS effects were also observed in animals that never learned fear or extinction (i.e., CS-only). This raises the possibility that traumatic stress could have broader effects on the psychological function that are dependent on the PAG and midline thalamic nuclei. |
| Databáze: | OpenAIRE |
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