Sustained reductions of invasive infectious disease following general infant Haemophilus influenzae type b and pneumococcal vaccination in a Swedish Arctic region
| Autor: | Mats Sellin, Sven Arne Silfverdal, Urban Johansson Kostenniemi, David Norman |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Haemophilus Infections Adolescent Prevalence medicine.disease_cause Meningococcal disease Pneumococcal Infections Meningitis Bacterial Haemophilus influenzae Pneumococcal Vaccines 03 medical and health sciences 0302 clinical medicine Sepsis 030225 pediatrics Streptococcus pneumoniae medicine Humans 030212 general & internal medicine Child Haemophilus Vaccines Retrospective Studies Sweden Arctic Regions business.industry Neisseria meningitidis Infant Newborn Infant General Medicine medicine.disease Vaccination Infectious disease (medical specialty) Child Preschool Pediatrics Perinatology and Child Health Immunology Female business Meningitis |
| Zdroj: | Acta Paediatrica. 108:1871-1878 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/apa.14824 |
| Popis: | Vaccine-preventable pathogens causing severe childhood infections include Haemophilus influenzae type b (Hib), Streptococcus pneumoniae and Neisseria meningitidis. In this study conducted in a Swedish Arctic region, we evaluated the effects of general infant Hib and pneumococcal vaccination on invasive infectious diseases among children and assessed the need of meningococcal vaccination.We identified cases of bacterial meningitis and sepsis from diagnosis and laboratory registers in the Västerbotten Region, Sweden, during 1986-2015. We then reviewed medical records to confirm the diagnosis and extract data for assessing incidence changes, using an exploratory data analysis and a time-series analysis.Invasive Haemophilus disease declined by 89.1% (p 0.01), Haemophilus meningitis by 95.3% (p 0.01) and all-cause bacterial meningitis by 82.3% (p 0.01) in children aged 0 to four years following general infant Hib vaccination. Following pneumococcal vaccination, invasive pneumococcal disease declined by 84.7% (p 0.01), pneumococcal meningitis by 67.5% (p = 0.16) and all-cause bacterial meningitis by 48.0% (p = 0.23). Incidence of invasive meningococcal disease remained low during the study period.Remarkable sustained long-term declines of invasive infectious diseases in younger children occurred following infant Hib and pneumococcal vaccinations in this Swedish Arctic region. Despite not offering general infant meningococcal vaccination, incidence of invasive meningococcal disease remained low. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text