Trilineage response in severe aplastic anemia following long-term therapy with recombinant human granulocyte colony-stimulating factor
| Autor: | Tohru Inaba, Chihiro Shimazaki, Masao Nakagawa, Katsunori Okawa, Eishi Ashihara, Naohisa Fujita, Oku N, T Hirata, Hideo Goto |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_treatment Granulocyte Blood cell Bone Marrow Granulocyte Colony-Stimulating Factor medicine Humans Aplastic anemia Metenolone acetate Aged Chemotherapy business.industry Anemia Aplastic Hematology General Medicine medicine.disease Recombinant Proteins Granulocyte colony-stimulating factor Blood Cell Count Haematopoiesis medicine.anatomical_structure Methylprednisolone Immunology business medicine.drug |
| Zdroj: | Acta haematologica. 90(3) |
| ISSN: | 0001-5792 |
| Popis: | We investigated the effects of long-term therapy with recombinant human granulocyte colony-stimulating factor (rhG-CSF) in a 69-year-old man with severe aplastic anemia (SAA). The patient was too old to receive a bone marrow transplantation, and high-dose methylprednisolone and antilymphocyte globulin were ineffective. We administered rhG-CSF in combination with metenolone acetate. Trilineage blood cell components were recovered 6 months later. These findings suggest that long-term G-CSF therapy may be beneficial in patients with SAA who are not candidates for bone marrow transplantation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|