2-(4´-Aminobenzenamine)-pyrimidine, a new α-antagonist from Autonoë madeirensis
| Autor: | Alexandra Paulo, Peter J. Houghton, Maria Lurdes Gonçalves, J Hawkes, Catarina Dias, José Nascimento |
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| Přispěvatelé: | Repositório da Universidade de Lisboa |
| Rok vydání: | 2004 |
| Předmět: |
Male
Pharmacotoxicology Pyrimidine Stereochemistry Pharmaceutical Science Alpha (ethology) Autonoe madeirensis Pharmacology Biology α1 adrenergic receptor Analytical Chemistry chemistry.chemical_compound Phenylephrine Vas Deferens Drug Discovery Liliaceae Animals Rats Wistar Adrenergic alpha-Antagonists Dose-Response Relationship Drug Plant Extracts Organic Chemistry Antagonist Muscle Smooth Rats Pyrimidines Complementary and alternative medicine chemistry Molecular Medicine Muscle Contraction Phytotherapy |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 0032-0943 |
| Popis: | A new natural pyrimidine derivative, 2-(4´-aminobenzenamine)-pyrimidine (1), was isolated from the bulbs of Autonoë madeirensis, a Hyacinthaceae of Madeira Archipelago (Portugal) and the structure determined on the basis of spectroscopic data. As some pyrimidine compounds are important alfa-1-adrenergic antagonists, we investigated the effect of 1 in the rat vas deferens contractility induced by the alfa-1-agonist phenylephrine. In concentrations virtually devoid of effect on the rat vas deferens contractility, 1 shifted to the right the concentration-response curves of phenylephrine without changing the maximal effect. These results provide evidence that 1 acts as an alfa-1-adrenoceptor antagonist and suggest a competitive mechanism of action. Faculdade de Farmácia (Centro de Estudos de Ciências Farmacêuticas e Unit of Pharmacology and Pharmacotoxicology) |
| Databáze: | OpenAIRE |
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