Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CT
| Autor: | Marija Pfeifer, Petra Tomše, Luka Lezaic, Marko Hočevar, Tomaz Kocjan, U Simoncic, Mojca Jensterle Sever, Sebastijan Rep |
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| Rok vydání: | 2015 |
| Předmět: |
standardized up-take value
endocrine system diseases R895-920 Lesion Scan time Medical physics. Medical radiology. Nuclear medicine Medicine Radiology Nuclear Medicine and imaging In patient Parathyroid adenoma PET-CT business.industry Thyroid triple-phase lesions representing enlarged parathyroid tissue medicine.disease medicine.anatomical_structure Oncology retention index [18f]-fluorocholine pet/ct medicine.symptom business Nuclear medicine 18F-fluorocholine lesion contrast Primary hyperparathyroidism Research Article |
| Zdroj: | Radiology and oncology (Ljubljana) Radiology and Oncology, Vol 49, Iss 4, Pp 327-333 (2015) Radiology and Oncology |
| ISSN: | 1581-3207 |
| Popis: | Background. Parathyroid adenomas, the most common cause of primary hyperparathyroidism, are benign tumours which autonomously produce and secrete parathyroid hormone. [18F]-fluorocholine (FCH), PET marker of cellular proliferation, was recently demonstrated to accumulate in lesions representing enlarged parathyroid tissue; however, the optimal time to perform FCH PET/CT after FCH administration is not known. The aim of this study was to determine the optimal scan time of FCH PET/CT in patients with primary hyperparathyroidism. Patients and methods. 43 patients with primary hyperparathyroidism were enrolled in this study. A triple-phase PET/CT imaging was performed five minutes, one and two hours after the administration of FCH. Regions of interest (ROI) were placed in lesions representing enlarged parathyroid tissue and thyroid tissue. Standardized uptake value (SUVmean), retention index and lesion contrast for parathyroid and thyroid tissue were calculated. Results. Accumulation of FCH was higher in lesions representing enlarged parathyroid tissue in comparison to the thyroid tissue with significantly higher SUVmean in the second and in the third phase (p < 0.0001). Average retention index decreased significantly between the first and the second phase and increased significantly between the second and the third phase in lesions representing enlarged parathyroid tissue and decreased significantly over all three phases in thyroid tissue (p< 0.0001). The lesion contrast of lesions representing enlarged parathyroid tissue and thyroid tissue was significantly better in the second and the third phase compared to the first phase (p < 0.05). Conclusions. According to the results the optimal scan time of FCH PET/CT for localization of lesions representing enlarged parathyroid tissue is one hour after administration of the FCH. |
| Databáze: | OpenAIRE |
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