Carbapenemase-producing Enterobacteriaceae and Aeromonas spp. present in wastewater treatment plant effluent and nearby surface waters in the US

Autor: Joshua B. Daniels, Dimitria A. Mathys, Gregory A. Ballash, Rachael J. Adams, David M. Stuever, Sydnee M. Feicht, Amy L. Albers, Thomas E. Wittum, Susan V. Grooters, Dixie F. Mollenkopf
Rok vydání: 2019
Předmět:
Veterinary medicine
Sanitization
Marine and Aquatic Sciences
Wastewater
Pathology and Laboratory Medicine
Medical Waste
Klebsiella Pneumoniae
Klebsiella
Drug Resistance
Multiple
Bacterial
Limnology
Medicine and Health Sciences
Public and Occupational Health
Water pollution
Groundwater
0303 health sciences
Multidisciplinary
biology
Contamination
Pollution
Hospitals
Bacterial Pathogens
Chemistry
Infectious Diseases
surgical procedures
operative
Aeromonas
Medical Microbiology
Physical Sciences
Medicine
Sewage treatment
Pathogens
Research Article
circulatory and respiratory physiology
Infectious Disease Control
Science
Enterobacter
Portable water purification
Microbiology
Water Purification
03 medical and health sciences
Surface Water
Ammonia
Animals
Humans
Microbial Pathogens
Effluent
Disease Reservoirs
030304 developmental biology
Bacteria
030306 microbiology
Ecology and Environmental Sciences
Water Pollution
Organisms
Chemical Compounds
Biology and Life Sciences
biology.organism_classification
United States
Health Care
Disinfection
Carbapenem-Resistant Enterobacteriaceae
Earth Sciences
Environmental science
Preventive Medicine
Hydrology
Surface water
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0218650 (2019)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0218650
Popis: Carbapenemase-producing bacteria (CPB) are rare, multidrug resistant organisms most commonly associated with hospitalized patients. Metropolitan wastewater treatment plants (WWTP) treat wastewater from large geographic areas which include hospitals and may serve as epidemiologic reservoirs for the maintenance or expansion of CPB that originate from hospitals and are ultimately discharged in treated effluent. However, little is known about the potential impact of these WWTP CPB on the local surface water and their risk to the public health. In addition, CPB that are present in surface water may ultimately disseminate to intensively-managed animal agriculture facilities where there is potential for amplification by extended-spectrum cephalosporins. To better understand the role of WWTPs in the dissemination of CPB in surface waters, we obtained samples of treated effluent, and both upstream and downstream nearby surface water from 50 WWTPs throughout the US. A total of 30 CPB with clinically-relevant genotypes were recovered from 15 WWTPs (30%) of which 13 (50%) serviced large metropolitan areas and 2 (8.3%) represented small rural populations (P < 0.05). Recovery of CPB was lowest among WWTPs that utilized ultraviolet radiation for primary disinfection (12%), and higher (P = 0.11) for WWTPs that used chlorination (42%) or that did not utilize disinfection (50%). We did not detect a difference in CPB recovery by sampling site, although fewer CPB were detected in upstream (8%) compared to effluent (20%) and downstream (18%) samples. Our results indicate that WWTP effluent and nearby surface waters in the US are routinely contaminated with CPB with clinically important genotypes including those producing Klebsiella pneumoniae carbapenemase (KPC) and New Delhi metallo-beta-lactamase (NDM). This is a concern for both public health and animal agriculture because introduction of CPB into intensively managed livestock populations could lead to their amplification and foodborne dissemination.
Databáze: OpenAIRE
Externí odkaz: