Validation of an in vitro sun protection factor (SPF) method in blinded ring-testing
| Autor: | Ludger Kolbe, C. Trullás Cabanas, G. Wiener, M. Contier, Paul J. Matts, C. Tricaud, Marc Pissavini, V. Nollent, E. Dietrich, A. Lauer, F. Boyer, E. Meredith |
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| Rok vydání: | 2018 |
| Předmět: |
Aging
010405 organic chemistry Sun protection Pharmaceutical Science Dermatology Test method 01 natural sciences Confidence interval Pearson product-moment correlation coefficient 0104 chemical sciences 030207 dermatology & venereal diseases 03 medical and health sciences symbols.namesake 0302 clinical medicine Colloid and Surface Chemistry Sun protection factor Chemistry (miscellaneous) Acceptance testing Drug Discovery Statistics symbols Mathematics |
| Zdroj: | International journal of cosmetic science. |
| ISSN: | 1468-2494 |
| Popis: | OBJECTIVE The objective of this work was to investigate the utility of a new in vitro SPF test method in blinded ring-testing, against new ISO acceptance criteria. METHODS Twenty four blinded, commercial, emulsion-type, primary sunscreen products, covering the full range of labelled SPF in Europe (SPF6 - 50+), were tested by three test institutes using the current ISO24444:2010 In Vivo SPF Test Method and simultaneously by three separate test laboratories using a new candidate in vitro SPF test method, developed under the leadership of Cosmetics Europe (CE). The resulting relationship between in vitro SPF and in vivo SPF values was then compared with acceptance criteria developed recently by the International Standards (ISO) TC217/WG7 Sun Protection Test Methods Working Group. RESULTS Analysis of the mean inter-laboratory in vitro and mean inter-institute in vivo SPF values revealed a strong correlation between in vitro and in vivo values, with a Pearson correlation coefficient of r2 = 0.88 (P |
| Databáze: | OpenAIRE |
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