Etoposide, doxorubicin, cyclophosphamide and high-dose betamethasone (EACB) as outpatient salvage therapy for refractory multiple myeloma
| Autor: | M. Järnmark, H. Gyllenhammar, A.-M. Udén, Bengt Smedmyr, G. Brenning, Kristina Carlson, Astrid Gruber, M. Ohrling, R. Hast, C. Paul, Anders Österborg, Fredrik Celsing, G. Gahrton, Bengt Simonsson, Eva Kimby, Olle Linder, Bertil Johansson, Gunnar Juliusson, Richard A. Lerner, M. Björeman, Karl Merk, Håkan Mellstedt, Eva Ösby, Erik Svedmyr, Magnus Björkholm, A.-M. Stalfelt, G. Grimfors |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Cyclophosphamide medicine.drug_class medicine.medical_treatment Drug Resistance Salvage therapy Gastroenterology Betamethasone Drug Administration Schedule Actuarial Analysis Recurrence Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Multiple myeloma Etoposide Aged Neoplasm Staging Aged 80 and over Salvage Therapy Chemotherapy business.industry Age Factors Hematology General Medicine Middle Aged medicine.disease Survival Analysis Surgery Regimen Doxorubicin Corticosteroid business Multiple Myeloma medicine.drug Follow-Up Studies |
| Zdroj: | European journal of haematology. 51(1) |
| ISSN: | 0902-4441 |
| Popis: | Fifty-six patients with refractory multiple myeloma were treated with intermittent courses of etoposide, doxorubicin, cyclophosphamide and high-dose betamethasone (EACB) every 4th week. The overall response rate was 30%. Durable remissions exceeding 1 year were obtained in 12 of the 17 responding patients. A significant prolongation of the survival time was found for responding patients (median 13 months) compared to those patients who did not respond (median 9 months) to EACB therapy (p = 0.01). A low frequency of neutropenic fever episodes was noted compared to other salvage treatment regimens. The EACB regimen was usually well tolerated and could be administered safely on an out-patient basis. This regimen might be an alternative especially for elderly patients unresponsive to initial therapy. |
| Databáze: | OpenAIRE |
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