Risk of Alzheimer's disease and environmental bisphenol A exposure
| Autor: | Ayse Basak Engin, Atilla Engin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty Type 2 diabetes 010501 environmental sciences Toxicology medicine.disease_cause 01 natural sciences 03 medical and health sciences Insulin resistance Internal medicine Diabetes mellitus medicine Receptor Neuroinflammation 0105 earth and related environmental sciences urogenital system business.industry Neurotoxicity medicine.disease 030104 developmental biology Endocrinology NMDA receptor business hormones hormone substitutes and hormone antagonists Oxidative stress |
| Zdroj: | Current Opinion in Toxicology. 25:36-41 |
| ISSN: | 2468-2020 |
| DOI: | 10.1016/j.cotox.2021.03.003 |
| Popis: | Environmental bisphenol A (BPA) exposure and bioaccumulation are higher than expected levels. In the long run, continuing BPA exposure impairs synaptic transmission and contributes to BPA-induced cognitive impairment, while increasing type 2 diabetes risk via promoting pancreatic β-cell death. BPA-insulin-Alzheimer’s disease (AD) axis represents a neuro-endocrine disorder and is termed as “Type 3 Diabetes”. BPA elevates oxidative stress and amyloid-beta accumulation in the AD brain, while increasing neuroinflammation and tau-phosphorylation. Neuronal viability is protected at high glucose concentration and insulin resistance conditions by N-methyl- d -aspartate (NMDA) receptor antagonists. Interestingly, despite its NMDA receptor suppressive effect, BPA contributes to neurotoxicity. Conversely, improvement of NMDA receptor functions shows protective effects against BPA-induced neurotoxicity. Thus, the mechanism of BPA neurotoxicity remains to be clarified. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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