Evidence of Change in Brain Activity among Childhood Cancer Survivors Participating in a Cognitive Remediation Program
| Autor: | Yimei Li, Raymond K. Mulhern, Robert J. Ogg, Robert W. Butler, Heather M. Conklin, Ping Zou |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Brain activity and meditation Pilot Projects Brain mapping Cognition Physical medicine and rehabilitation Continuous performance task Neoplasms medicine Humans Attention Survivors Child Brain Mapping medicine.diagnostic_test Supplementary motor area Brain Original Empirical Articles General Medicine Magnetic Resonance Imaging Clinical trial Psychiatry and Mental health Clinical Psychology Neuropsychology and Physiological Psychology medicine.anatomical_structure Cognitive remediation therapy Female Functional magnetic resonance imaging Psychology Psychomotor Performance Clinical psychology |
| Zdroj: | Archives of Clinical Neuropsychology. 27:915-929 |
| ISSN: | 1873-5843 0887-6177 |
| DOI: | 10.1093/arclin/acs095 |
| Popis: | Increased understanding of the underlying mechanisms of cognitive remediation is needed to facilitate development of intervention strategies for childhood cancer survivors experiencing cognitive late effects. Accordingly, a pilot functional magnetic resonance imaging (fMRI) study was conducted with 14 cancer survivors (12.02 ± 0.09 years old), who participated in a cognitive remediation clinical trial, and 28 healthy children (12.7 ± 0.6 years old). The ventral visual areas, cerebellum, supplementary motor area, and left inferior frontal cortex were significantly activated in the healthy participants during a continuous performance task. In survivors, brain activation in these regions was diminished at baseline, and increased upon completion of remediation and at a 6-month follow-up. The fMRI activation index for each region of interest was inversely associated with the Conners' Clinical Competence Index (p |
| Databáze: | OpenAIRE |
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