Outbreak of a South West Pacific clone Panton–Valentine leucocidin-positive meticillin-resistant Staphylococcus aureus infection in a UK neonatal intensive care unit

Autor: Anthony W. Burgess, Fritz A. Mühlschlegel, Angela M. Kearns, Bruno Pichon, J. Q. Nash, J. Sedgwick, Z. Nixon, D. Weston, H. Ali, G. Ashford, Vimal Vasu
Rok vydání: 2012
Předmět:
Adult
Male
Methicillin-Resistant Staphylococcus aureus
Microbiology (medical)
medicine.medical_specialty
Neonatal intensive care unit
Virulence Factors
Health Personnel
Philippines
Bacterial Toxins
Exotoxins
Microbial Sensitivity Tests
Quinolones
medicine.disease_cause
Disease Outbreaks
Microbiology
Leukocidins
Intensive Care Units
Neonatal
Internal medicine
Disease Transmission
Infectious
Humans
Medicine
Typing
Infection Control
Molecular Epidemiology
Travel
business.industry
MRSA colonization
Infant
Newborn
Infant
Outbreak
General Medicine
Staphylococcal Infections
biochemical phenomena
metabolism
and nutrition
bacterial infections and mycoses
United Kingdom
Anti-Bacterial Agents
Molecular Typing
Neonatal infection
Infectious Diseases
Meticillin resistant
Staphylococcus aureus
Carrier State
Panton valentine leucocidin
Female
business
Zdroj: Journal of Hospital Infection. 80:293-298
ISSN: 0195-6701
DOI: 10.1016/j.jhin.2011.12.019
Popis: Summary Background Panton–Valentine leucocidin-positive meticillin-resistant Staphylococcus aureus (PVL-MRSA) has become a globally common cause of community-acquired infections. Aim We report an outbreak of PVL-MRSA in a regional neonatal unit in the UK involving three babies and three staff members. Methods Quinolone susceptibility was helpful in identifying potential PVL-MRSA but toxin gene profiling and sequence-based typing were required to distinguish between two PVL-MRSA strains present in the unit. Findings All three symptomatic babies and two staff carriers, one of whom was symptomatic, were found to be carrying the South West Pacific (SWP) clone of PVL-MRSA (ST30). One of the staff carriers had recently visited the Philippines and was thought to be the source of the outbreak. Control was established using standard infection control procedures but one baby with relapsing MRSA colonization has required more than 100 days in isolation. Conclusion This is the first reported neonatal outbreak associated with the SWP clone in the UK. Our study highlights the potential risk of further introductions of this organism by healthcare staff or patients epidemiologically linked with the Philippines.
Databáze: OpenAIRE
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