A randomized trial of rotavirus vaccine versus sucrose solution for vaccine injection pain
| Autor: | Supriya Lamba, Eitan Weinberg, Anna Taddio, Daniel Flanders, Moshe Ipp, Carol McNair, Andrew F. Ilersich, Charmy Vyas |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Parents Sucrose medicine.medical_specialty Demographics Analgesic Administration Oral Pain Vaccines Attenuated Injections Intramuscular law.invention Sucrose solution Randomized controlled trial law Internal medicine Humans Medicine Pain Measurement Analgesics Pain score General Veterinary General Immunology and Microbiology business.industry Vaccination Rotavirus Vaccines Public Health Environmental and Occupational Health Infant Pain scale Rotavirus vaccine Healthy Volunteers Infectious Diseases Anesthesia Molecular Medicine Female business |
| Zdroj: | Vaccine. 33:2939-2943 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2015.04.057 |
| Popis: | Objective Sucrose solutions are analgesic in infants. Oral rotavirus vaccine contains sucrose, however, it is not known if it possesses analgesic properties. The objective was to compare the analgesic effectiveness of rotavirus vaccine to sucrose solution when administered prior to injectable vaccines. Methods Infants 2–4 months of age receiving oral rotavirus vaccine and two separate injectable vaccines on the same day were randomized to rotavirus vaccine (Rotarix™) first followed by the injectable vaccines and sucrose (Tootsweet™) afterwards, or vice versa. Pain was assessed by blinded raters using the Numerical Rating Scale (NRS, range 0–10) (parents, clinicians), or Modified Behavioural Pain Scale (MBPS, range 0–10) and cry duration (observers). Data were analyzed using t -tests or χ 2 -tests; Bonferroni correction was applied to correct for multiple comparisons, as appropriate. Results Altogether, 120 infants participated: 60 were randomized to rotavirus vaccine first. Groups did not differ in demographics, including; age ( p = 0.448) and sex ( p = 0.464). The mean pain score (standard deviation) for both vaccine injections did not differ between infants given rotavirus vaccine first versus sucrose solution first: observer MBPS, parent NRS and clinician NRS scores were 7.4 (1.6) vs. 7.7 (1.6), 4.9 (2.1) vs. 5.8 (2.1), and 4.2 (2.1) vs. 4.6 (2.2), respectively. Similarly, there was no difference between groups in cry duration. Conclusion Rotavirus vaccine did not differ from sucrose solution in reducing injection-induced pain. Based on the findings, it is recommended that rotavirus vaccine be administered prior to injectable vaccines in infants aged 2 and 4 months. |
| Databáze: | OpenAIRE |
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