Treatment of acute otitis externa with ciprofloxacin otic 0.2% antibiotic ear solution
| Autor: | M Nematian-Samani, A Eichel, Ralph Mösges |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class efficacy Antibiotics Cutis Ear solution Inflammation Review RM1-950 ear solution Auditory canal ciprofloxacin antibiotic Acute otitis externa medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Chemical Health and Safety business.industry General Medicine otitis externa Dermatology Surgery Ciprofloxacin Therapeutics. Pharmacology medicine.symptom business Safety Research medicine.drug |
| Zdroj: | Therapeutics and Clinical Risk Management, Vol 2011, Iss default, Pp 325-326 (2011) Therapeutics and Clinical Risk Management |
| ISSN: | 1176-6336 |
| Popis: | R Mösges, M Nematian-Samani, A EichelInstitute of Medical Statistics, Informatics and Epidemiology, Faculty of Medicine, University of Cologne, GermanyBackground/objective: An inflammation of the cutis and subcutis of the external auditory canal is a primary symptom in cases of acute otitis externa. It is usually treated locally, since this type of therapy ensures a high concentration of the drug and interacts at the site of inflammation with no systemic effects. This systematic review compares the efficacy of treatment using a ciprofloxacin 0.2% solution with other therapeutic options.Methods: After compiling a catalog of search terms, medical databases were searched systematically for randomized, controlled studies. This search initially yielded a total of 38 studies which were then evaluated by three independent reviewers. The number of studies was subsequently reduced to 14: six studies using a ciprofloxacin 0.2% solution, and eight studies using both 0.2% and 0.3% solutions.Results: The studies included in the review demonstrate the statistical equivalence between the ciprofloxacin solution (0.2%) and the reference products PNH (a combination of polymyxin B, neomycin sulfate and hydrocortisone), auriculum powder, and a ciprofloxacin foam with respect to the cure rate. The research groups consistently observed high in vitro activity of ciprofloxacin against Pseudomonas aeruginosa.Conclusion: This systematic review confirms the hypothesis of ciprofloxacin's noninferiority in the treatment of otitis externa, in terms of the cure rate and microbiological eradication.Keywords: otitis externa, ciprofloxacin, antibiotic, ear solution, efficacy |
| Databáze: | OpenAIRE |
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