Ultra-deep sequencing provides insights into the virology of hepatitis C super-infections in a case of three sequential infections with different genotypes
| Autor: | Adele L. McCormick, R. Bridget Ferns, Eleni Nastouli, Daniel P. Webster, Sanjay Bhagani, Laura Waters, Emily Chung, Paul R. Grant, Roberto Rigatti, Miao He |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Genotype Hepacivirus medicine.disease_cause Men who have sex with men Virology medicine Humans Intravenous drug biology virus diseases High-Throughput Nucleotide Sequencing Ultra deep sequencing Hepatitis C Middle Aged Viral Load medicine.disease biology.organism_classification Infectious Diseases Superinfection RNA Viral 5' Untranslated Regions Viral load |
| Zdroj: | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 70 |
| ISSN: | 1873-5967 |
| Popis: | The current epidemic of Hepatitis C infection in HIV-positive men who have sex with men is associated with increasing use of recreational drugs. Multiple HCV infections have been reported in haemophiliacs and intravenous drug users. Using ultra-deep sequencing analysis, we present the case of an HIV-positive MSM with evidence of three sequential HCV infections, each occurring during the acute phase of the preceding infection, following risk exposures. We observed rapid replacement of the original strain by the incoming genotype at subsequent time points. The impact of HCV super-infection remains unclear and UDS may provide new insights. |
| Databáze: | OpenAIRE |
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