Severe megaloblastic anaemia presenting as pancytopenia with red cell hypoplasia and elevated serum cobalamin and cobalamin binding proteins
| Autor: | H.A. O'brien, N.A. Sourial |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Myeloid Anemia Megaloblastic Pancytopenia Biology Cobalamin chemistry.chemical_compound Folic Acid Bone Marrow hemic and lymphatic diseases Internal medicine polycyclic compounds medicine Humans heterocyclic compounds Megaloblastic anemia Erythroid Precursor Cells Transcobalamins Hyperplasia integumentary system nutritional and metabolic diseases Hematology Middle Aged medicine.disease Hematopoietic Stem Cells Hypoplasia Vitamin B 12 medicine.anatomical_structure Endocrinology chemistry Immunology Cobalamin binding Erythropoiesis Female Bone marrow |
| Zdroj: | Clinical and laboratory haematology. 13(3) |
| ISSN: | 0141-9854 |
| Popis: | In severe megaloblastic anaemia due to folate or cobalamin deficiency the bone marrow is usually hypercellular with megaloblastic change in erythropoiesis and giant metamyelocytes in the myeloid series. We report an unusual case of megaloblastic anaemia with marked erythroid hypoplasia and myeloid hyperplasia; the serum cobalamin and unsaturated cobalamin binding capacity were both grossly elevated. |
| Databáze: | OpenAIRE |
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