Deep Penetration of a PDT Drug into Tumors by Non-covalent Drug-Gold Nanoparticle Conjugates
| Autor: | Joseph D. Meyers, Yu Cheng, Malcolm E. Kenney, Ann-Marie Broome, James P. Basilion, Clemens Burda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Drug
Biodistribution Fluorescence-lifetime imaging microscopy media_common.quotation_subject Metal Nanoparticles Mice Nude Antineoplastic Agents Pharmacology Biochemistry Catalysis Article Mice Colloid and Surface Chemistry Drug Delivery Systems Pharmacokinetics Glioma Cell Line Tumor medicine Fluorescence Resonance Energy Transfer Animals Tissue Distribution media_common Fluorescent Dyes Chemistry Cancer General Chemistry medicine.disease Xenograft Model Antitumor Assays Rats Photochemotherapy Drug delivery Female Gold Conjugate |
| Popis: | Efficient drug delivery to tumors is of ever increasing importance. Single-visit diagnosis and treatment sessions are the goal of future theranostics. In this paper, a non-covalent PDT cancer drug-gold nanoparticle (Au NP) conjugate system performed a rapid drug release and deep penetration of the drug into tumors within hours. The drug delivery mechanism of the PDT drug through Au NPs into tumors by passive accumulation was investigated via fluorescence imaging, elemental analysis, and histological staining. The pharmacokinetics of the conjugates over a 7 day test period showed fast drug excretion, as monitored via the fluorescence of the drug in urine. Moreover, the biodistribution of Au NPs in this study period indicated clearance of the NPs from the mice. This study suggests that the non-covalent delivery via Au NPs provides an attractive approach for cancer drugs to penetrate deep into the center of tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|