The relationship between neutrophil to lymphocyte ratio and blood pressure variability in hypertensive and normotensive subjecs
| Autor: | Mehmet Salih Aydin, Oner Ozdogan, Sermin Kaymak, Hüseyin Dursun, Cenk Ekmekci, Barış Kılıçaslan, İbrahim Susam |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male lcsh:Internal medicine lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty Ambulatory blood pressure Neutrophils Cross-sectional study lcsh:Medicine Leukocyte Count Internal medicine Humans Medicine Lymphocytes Neutrophil to lymphocyte ratio lcsh:RC31-1245 Aged biology Dipper business.industry lcsh:R blood pressure Middle Aged biology.organism_classification blood pressure monitoring Cross-Sectional Studies Blood pressure ROC Curve lcsh:RC666-701 Hypertension Ambulatory Linear Models Cardiology HN group Female Multiple linear regression analysis ambulatory hypertension inflammation n/l ratio Cardiology and Cardiovascular Medicine business |
| Zdroj: | Türk Kardiyoloji Derneği Arşivi, Vol 43, Iss 1, Pp 18-24 (2015) |
| ISSN: | 1016-5169 |
| Popis: | Objectives: Blood pressure (BP) variability is associated with hypertensive (HT) target organ damage and cardiovascular events. The aim of this study was to investigate the relation between neutrophil to lymphocyte ratio (NLR) and BP variabil- ity in hypertensive and normotensive subjects. Study design: In this cross-sectional study, 150 subjects (63 male, mean age 52.1+-5.2 years) were enrolled. In all patients, blood samples and 24-hour ambulatory blood pressure (BP) monitoring were obtained. According to 24-hour ambulatory BP results, participants were divided into four investigation categories. Group 1= Normotensive dipper (ND), Group 2= Normotensive non-dipper (NN), Group 3= HT dipper (HD), Group 4= HT non-dipper (HN). Results: Highest NLR values were determined in the HN group (p=0.005 vs. ND, p=0.046 vs. NN and p0.05, for all). NLR was correlated with night systolic blood pressure (SBP) (r=0.178, p=0.031), night diastolic blood pressure (DBP) (r=0.176, p=0.032) and BP variation rate (r=- 0.246, p=0.003). Multiple linear regression analysis showed BP variation rate to be an independent predictor of high NLR value (β=0.186, 95% CI=0.918-0.982, p=0.044). In ROC anal- ysis, a level of NLR>2.7 predicted non-dipper HT with 83% sensitivity and 65% specificity (ROC area under curve: 0.653, 95% CI=0.565-0.741, p=0.001). Conclusion: In the present study, we found that NLR levels were significantly correlated with BP variability. The measure- ment of NLR may be used to indicate increased risk of HT- related adverse cardiovascular events. |
| Databáze: | OpenAIRE |
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