Contrast sensitivity to spatial gratings in moderate and dim light conditions in patients with diabetes in the absence of diabetic retinopathy
| Autor: | Mohammad Aghazadeh Amiri, Mojtaba Malek, Anoushiravan Rahimi, Hamid Safi, Hamid Ahmadieh, Mohammad Haeri, Sare Safi, Afsaneh Raeesi, Frank A. Middleton, Mehdi Yaseri, Eduardo Solessio |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Visual acuity Endocrinology Diabetes and Metabolism media_common.quotation_subject Logistic regression 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Ophthalmology medicine Contrast (vision) Pathophysiology/Complications media_common contrast sensitivity diabetes Receiver operating characteristic business.industry Diabetic retinopathy medicine.disease Surgery diabetic retinopathy 030221 ophthalmology & optometry Spatial frequency medicine.symptom business 030217 neurology & neurosurgery Retinopathy |
| Zdroj: | BMJ Open Diabetes Research & Care |
| ISSN: | 2052-4897 |
| DOI: | 10.1136/bmjdrc-2017-000408 |
| Popis: | Objective To evaluate the ability of contrast sensitivity (CS) to discriminate loss of visual function in diabetic subjects with no clinical signs of retinopathy relative to that of normal subjects. Research design and methods In this prospective cross-sectional study, we measured CS in 46 diabetic subjects with a mean age of 48±6 years, a best-corrected visual acuity of 20/20 and no signs of diabetic retinopathy. The CS in these subjects was compared with CS measurements in 46 normal control subjects at four spatial frequencies (3, 6, 12, 18 cycles per degree) under moderate (500 lux) and dim (less than 2 lux) background light conditions. Results CS was approximately 0.16 log units lower in patients with diabetes relative to controls both in moderate and in dim background light conditions. Logistic regression classification and receiver operating characteristic curve analysis indicated that CS analysis using two light conditions was more accurate (0.78) overall compared with CS analysis using only a single illumination condition (accuracy values were 0.67 and 0.70 in moderate and dim light conditions, respectively). Conclusions Our results showed that patients with diabetes without clinical signs of retinopathy exhibit a uniform loss in CS at all spatial frequencies tested. Measuring the loss in CS at two spatial frequencies (3 and 6 cycles per degree) and two light conditions (moderate and dim) is sufficiently robust to classify diabetic subjects with no retinopathy versus control subjects. |
| Databáze: | OpenAIRE |
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