Antenatal Micronutrients and the Mitochondrial Genome: A Glimpse of Future Nutritional Investigation
| Autor: | Sun Eun Lee, Keith P. West, Michael Fenech |
|---|---|
| Přispěvatelé: | Lee, Sun Eun, Fenech, Michael F, West, Keith P |
| Rok vydání: | 2019 |
| Předmět: |
Mitochondrial DNA
DNA Copy Number Variations multiple micronutrients Medicine (miscellaneous) Prenatal care Mitochondrion Genome DNA Mitochondrial Pregnancy Medicine Humans oxidative stress Micronutrients Original Research Article Genetics Nutrition and Dietetics business.industry mtDNA-CN Biochemical Molecular and Genetic Mechanisms Micronutrient iron and folic acid mitochondrial DNA copy number Indonesia Dietary Supplements Genome Mitochondrial supplementation Female business |
| Zdroj: | The Journal of Nutrition |
| ISSN: | 1541-6100 |
| Popis: | Background The Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT) in Lombok, Indonesia showed that maternal multiple micronutrients (MMN), as compared with iron and folic acid (IFA), reduced fetal loss, early infant mortality, and low birth weight. Mitochondria play a key role during pregnancy by providing maternal metabolic energy for fetal development, but the effects of maternal supplementation during pregnancy on mitochondria are not fully understood. Objective The aim of this study was to assess the impact of MMN supplementation on maternal mitochondrial DNA copy number (mtDNA-CN). Methods We used archived venous blood specimens from pregnant women enrolled in the SUMMIT study. SUMMIT was a cluster-randomized double-blind controlled trial in which midwives were randomly assigned to distribute MMN or IFA to pregnant women. In this study, we selected 108 sets of paired baseline and postsupplementation samples (MMN = 54 and IFA = 54). Maternal mtDNA-CN was determined by real-time quantitative polymerase chain reaction in baseline and postsupplementation specimens. The association between supplementation type and change in mtDNA-CN was performed using rank-based estimation for linear models. Results In both groups, maternal mtDNA-CN at postsupplementation was significantly elevated compared with baseline (P |
| Databáze: | OpenAIRE |
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