GATA‐binding protein 3 and gross cystic disease fluid protein 15 as a potential diagnostic marker for extramammary Paget's disease
| Autor: | Razib Hossain, Mamitaro Ohtsuki, Koji Kamiya, Mayumi Komine, Miho Kimura, Soichiro Kado, Meijuan Jin, Takeo Maekawa |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty extramammary business.industry diagnosis Diagnostic marker RC581-607 medicine.disease Extramammary Paget's disease dermatology sensitivity and specificity RL1-803 Paget Disease GROSS CYSTIC DISEASE FLUID PROTEIN immunohistochemistry medicine Immunology and Allergy Immunohistochemistry Immunologic diseases. Allergy business Paget disease Gata-Binding Protein |
| Zdroj: | Journal of Cutaneous Immunology and Allergy, Vol 4, Iss 6, Pp 154-158 (2021) |
| ISSN: | 2574-4593 |
| Popis: | Objectives The aim of this study was to evaluate the expression of GCDFP15 and GATA‐binding protein 3 (GATA‐3) in extramammary Paget's disease (EMPD) skin and serum samples and to assess their availability as tumor markers for the diagnosis and assessment of disease severity in primary EMPD. Methods Skin samples and serum samples were obtained from 16 patients with primary EMPD (10 cases from male, six cases from female; stage IA six cases, stage IB seven cases, stage III one case, stage IV two cases). By immunohistochemistry, the expression of GCDFP15 and GATA3 was examined in skin specimens. The serum levels of GCDFP15 and GATA3 were quantified by ELISA. Results In our study, eight out of 16 patients showed positive staining for GCDFP15. In contrast, all 16 patients showed positive staining for GATA‐3. Immunohistochemical staining of EMPD skin samples showed that GATA‐3 had a higher positivity rate than GCDFP15. However, there was no correlation between serum levels of GCDFP15 or GATA‐3 and the disease stage. Conclusion Our results indicate that GCDFP15 and GATA‐3 are useful for the diagnosis of primary EMPD, but not for monitoring disease progression, and suggest that GATA‐3 is a more reliable marker than GCDFP15 for the diagnosis of primary EMPD. |
| Databáze: | OpenAIRE |
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