| Autor: |
Daphne A. Haas-Kogan, Dipanjan Chowdhury, Sabine Mueller, Steven G. DuBois, Keith L. Ligon, Pratiti Bandopadhayay, Adam C. Resnick, William A. Weiss, Nathalene Truffaux, Jie Bian, Kevin X. Liu, Jean Zhao, John A. Alberta, Jing Ni, Whitney Fitts, Wojciech Fendler, Xiaodong Yang, David Kozono, Sharmistha Pal |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22419474.v1 |
| Popis: |
This file contains the supplementary figures (S1-S10) with legends and supplementary tables S1-S8. Supplementary Tables S1-S3 contain sequences for siRNA and primers used in RT-PCR, ChIP-PCR. Supplementary Tables S4-S8 contain the p-values for all pairwise comparisons performed in figures 3-6. Figure S1: CUDC-907 inhibits HDAC and PI3K activity. Figure S2: CUDC-907 synergizes with radiation. Figure S3: CUDC-907 reduces tomor cell proliferation in vivo. Figure S4:CUDC-907 induces cell cycle arrest and apoptosis. Figure S5:CUDC-907 enhances radiation induced DNA damage in vitro. Figure S6:Increase in DNA damage marker γ-H2AX is observed in vivo in the presence of CUDC-907. Figure S7:CUDC-907 reduces DNA damage protein. Figure S8: CUDC-907 impairs expression of NFκB and FOXM1. Figure S9:CUDC-907 interferes with nuclear localization of NFκB proteins. Figure S10:NFκB and FOXM1 knockdown induces DNA damage and cell viability. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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