Antivertigo agents. III. Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridine methyl homologs
| Autor: | Hiroshi Yamanaka, Shuji Kurashige, Yuh-Ichiro Ichikawa, Takao Sakamoto, Chikara Komuro, Hiroshi Miyazaki, Akira Shiozawa |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Chemical Phenomena
Bicyclic molecule Chemistry Stereochemistry Chemical modification General Chemistry General Medicine Methylation Nuclear magnetic resonance spectroscopy Ring (chemistry) Lithium diisopropylamide chemistry.chemical_compound Drug Discovery Pyridine Vertigo Humans Naphthyridines Methyl group |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 32:2522-2529 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.32.2522 |
| Popis: | 5-Methyl-(4a), 7-methyl-(4b), and 8-methyl-5, 6, 7, 8-tetrahydro-1, 6-naphthyridine (4c) were synthesized by chemical modification of pyridine derivatives. On the other hand, the synthesis of the compounds (20b, c) having a methyl group in the aromatic ring of 5, 6, 7, 8-tetrahydro-1, 6-naphthyridine was accomplished by the condensation of 1-benzyl-4-piperidinone with the corresponding 3-amino-enones followed by debenzylation. The pathway of the condensation is briefly discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|