Cyclic and sequential therapy with tamoxifen and medroxyprogesterone acetate in metastatic breast cancer
| Autor: | Thomas L. Dao, Dutzu Rosner, H. Halvorson, Takuma Nemoto, Jashbhai K. Patel |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Oncology Medroxyprogesterone medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Breast Neoplasms Medroxyprogesterone Acetate Drug Administration Schedule Internal medicine Antineoplastic Combined Chemotherapy Protocols Progesterone receptor medicine Humans Medroxyprogesterone acetate skin and connective tissue diseases Aged Clinical Trials as Topic Chemotherapy business.industry General Medicine Middle Aged medicine.disease Antiestrogen Metastatic breast cancer Tamoxifen Regimen Endocrinology Female Surgery Receptors Progesterone business medicine.drug |
| Zdroj: | Journal of Surgical Oncology. 41:226-229 |
| ISSN: | 1096-9098 0022-4790 |
| Popis: | A clinical trial of sequential tamoxifen and medroxyprogesterone acetate (MPA) was carried out in 36 women with metastatic breast cancer in order to evaluate the therapeutic efficacy of this regimen and to determine if tamoxifen would increase progesterone receptor (PR) levels and thereby increase response to MPA. Fourteen patients (39%) responded to this treatment, with the duration of remission ranging from 2 to 24 + months (the mean and median were 11 months). In 22 patients, PR levels were measured both before and after 7 days of tamoxifen administration. In PR- positive patients, PR changes induced by tamoxifen did not appear to increase the response rate. In PR-negative patients, PR became positive in 3 patients following tamoxifen treatment, with 2 of 3 responding to treatment, whereas in 11 others whose PR levels remained negative, only one response was observed. Our results suggest that potentiation by tamoxifen was not observed, since in our previous study, MPA alone was equally effective. Thus, tamoxifen and MPA should be given independently for palliation of metastatic breast cancer, and MPA should be administered following therapy with tamoxifen. |
| Databáze: | OpenAIRE |
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