Maturation and Emigration of Single-Positive Thymocytes
| Autor: | Shusong Zhang, Jin Lu, Qing Ge, Xi Xu, Qun Xuan, Pingping Li |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Cellular differentiation Thymic medulla T cell Immunology Recent Thymic Emigrant Review Article Biology Antigen Antigens CD Cell Movement T-Lymphocyte Subsets medicine Animals Humans Immunology and Allergy Lymphopoiesis Clonal Selection Antigen-Mediated Thymocytes Late stage Cell Differentiation Oxidation reduction General Medicine Cell biology Phenotype medicine.anatomical_structure lcsh:RC581-607 Oxidation-Reduction |
| Zdroj: | Clinical and Developmental Immunology Clinical and Developmental Immunology, Vol 2013 (2013) |
| ISSN: | 1740-2530 1740-2522 |
| DOI: | 10.1155/2013/282870 |
| Popis: | T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are “fully mature” and waiting to be exported at random or follow a “first-in-first-out” manner. Recent evidence, however, has revealed that the newly generated SP thymocytes undergo a multistage maturation program in the thymic medulla. Such maturation is followed by a tightly regulated emigration process and a further postthymic maturation of recent thymic emigrants (RTEs). This review summarizes recent progress in the late stage T cell development. The regulation of this developmental process is discussed. |
| Databáze: | OpenAIRE |
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