Revisiting the association between childhood trauma and psychosis in bipolar disorder: A quasi-dimensional path-analysis
| Autor: | Jean-Pierre Kahn, Katia M'Bailara, Helen L. Fisher, C. Henry, Marion Leboyer, Frank Bellivier, Mohamed Lajnef, Bruno Etain |
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| Přispěvatelé: | Etain, Bruno, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Variabilité de réponse aux Psychotropes (VariaPsy - U1144), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Fondation FondaMental [Créteil], Centre Psychothérapique de Nancy (CPN), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Laboratoire de psychologie:Santé et qualité de vie, Université Bordeaux Segalen - Bordeaux 2, Centre hospitalier Charles Perrens [Bordeaux], Université de Lorraine (UL), Pôle de Psychiatrie [Hôpital Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital H. Mondor - A. Chenevier, Hôpital Charles Perrens |
| Rok vydání: | 2016 |
| Předmět: |
Male
MESH: Psychiatric Status Rating Scales Marijuana Abuse Bipolar Disorder [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health Poison control Childhood trauma 0302 clinical medicine MESH: Bipolar Disorder Surveys and Questionnaires biology Adult Survivors of Child Abuse Psychiatry and Mental health Physical abuse Female medicine.symptom Psychology Clinical psychology Adult medicine.medical_specialty Psychosis Bipolar disorder MESH: Marijuana Abuse MESH: Psychotic Disorders Delusions 03 medical and health sciences Delusion Injury prevention medicine MESH: Adult Survivors of Child Abuse Humans MESH: Surveys and Questionnaires Psychiatry Biological Psychiatry Cannabis MESH: Delusions Psychiatric Status Rating Scales MESH: Humans CTQ tree MESH: Adult biology.organism_classification medicine.disease MESH: Male 030227 psychiatry Psychotic Disorders [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health MESH: Female 030217 neurology & neurosurgery |
| Zdroj: | Journal of Psychiatric Research Journal of Psychiatric Research, 2017, 84, pp.73-79. ⟨10.1016/j.jpsychires.2016.09.022⟩ Journal of Psychiatric Research, Elsevier, 2017, 84, pp.73-79. ⟨10.1016/j.jpsychires.2016.09.022⟩ Etain, B, Lajnef, M, Bellivier, F, Henry, C, M'bailara, K, Kahn, J P, Leboyer, M & Fisher, H L 2017, ' Revisiting the association between childhood trauma and psychosis in bipolar disorder : A quasi-dimensional path-analysis ', Journal of psychiatric research, vol. 84, pp. 73-79 . https://doi.org/10.1016/j.jpsychires.2016.09.022 |
| ISSN: | 1879-1379 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2016.09.022⟩ |
| Popis: | Background Childhood trauma has been associated with a more severe clinical expression of bipolar disorder (BD). However, the results that specifically associated traumatic events and psychotic features in BD have been inconsistent, possibly due to the low resolution of the phenotypes being used. Methods 270 normothymic patients with BD completed the Childhood Trauma Questionnaire (CTQ) and the Peters Delusion Inventory (PDI) that assessed 21 delusional beliefs. Patients were characterized for the lifetime presence of psychotic features during episodes and cannabis misuse in accordance with DSM-IV. We performed a series of path analyses to investigate the links from three types of childhood abuse (physical, sexual and emotional) directly to delusional beliefs and psychotic features, and indirectly through cannabis misuse. Results A first path analysis showed no link between any of the childhood abuse types and psychotic features when only a categorical definition of psychosis was used. When incorporating the quasi-dimensional measure of delusional beliefs in a second path analysis, we found that emotional and physical abuse and cannabis misuse were each directly associated with PDI score. PDI score and psychotic features were strongly correlated. Childhood abuse did not operate through cannabis misuse to increase delusional beliefs. Including type of BD in the model did not alter the results. Conclusion Emotional and physical abuse, but also cannabis misuse, increased delusional beliefs in patients with BD. Using a quasi-dimensional measure of psychotic symptoms in BD provided higher resolution of the psychosis phenotype and helped reconcile ambiguous findings from previous studies. |
| Databáze: | OpenAIRE |
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