Pepsinogen II Can Be a Potential Surrogate Marker of Morphological Changes in Corpus before and afterH. pyloriEradication
| Autor: | Ali Ali-Asgari, Seyed Mehdi Shahidi, Sadegh Massarrat, Nasrin Zendehdel, Manfred Stolte, Ashraf Mohamadkhani, Naser Rakhshani, Arghavan Haj-Sheykholeslami |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Moderate to severe medicine.medical_specialty Article Subject Pepsinogen C lcsh:Medicine macromolecular substances digestive system Gastroenterology General Biochemistry Genetics and Molecular Biology Helicobacter Infections Atrophy Double-Blind Method Pepsin Stomach Neoplasms Serum biomarkers Internal medicine Biomarkers Tumor medicine Humans Aged Helicobacter pylori General Immunology and Microbiology biology Surrogate endpoint lcsh:R General Medicine Middle Aged medicine.disease biology.organism_classification digestive system diseases Clinical Study biology.protein Pepsinogen II Female |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2014 (2014) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Background.The aim of this investigation is to study the relationship between gastric morphology and serum biomarkers before and afterHelicobacter pylorieradication.Methods. First-degree relatives of gastric cancer patients underwent gastroscopy before and 2.5 years afterH. pylorieradication. The morphological changes in two categories (normal to mild and moderate to severe) were compared with level of pepsinogens I and II before eradication (n=369), after eradication (n=115), and in those with persistent infection (n=250).Results: After eradication, pepsinogen I decreased to 70% and pepsinogen II to 45% of the previous values. Unlike pepsinogen II and pepsinogen I to II ratio that were affected by the severity of inflammation and atrophy in corpus in all groups, pepsinogen I generally did not change. After eradication, subjects with high mononuclear infiltration in corpus had lower pepsinogen I (54 versus 77.1 μ/mL), higher pepsinogen II (9.4 versus 6.9 μ/mL), and lower ratio (7.9 versus 11.6) than those without (P<0.05).Conclusion. Pepsinogen II is a good marker of corpus morphological changes before and afterH. pylorieradication. |
| Databáze: | OpenAIRE |
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