Retrospective Analysis of 28 Cases Confirmed for Primary Angiitis of the Central Nervous System by Biopsy
| Autor: | Gang Cheng, Hulin Zhao, Hongbo Chang, Ming Gao, Jian-Ning Zhang, Weidong Cao, Sheng-Li Guo, Peng Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Central Nervous System Male Pediatrics medicine.medical_specialty Time Factors Cyclophosphamide Adolescent medicine.medical_treatment Biopsy Disease Time-to-Treatment 03 medical and health sciences Young Adult 0302 clinical medicine Predictive Value of Tests Risk Factors medicine Humans Vasculitis Central Nervous System Pathological Glucocorticoids Craniotomy Retrospective Studies medicine.diagnostic_test business.industry Rehabilitation Therapeutic effect Middle Aged Prognosis Early Diagnosis Cohort Etiology Surgery Female Neurology (clinical) Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Immunosuppressive Agents medicine.drug |
| Zdroj: | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 29(12) |
| ISSN: | 1532-8511 |
| Popis: | OBJECTIVE The present study aimed to summarize the clinical characteristics, therapeutic effects, and long-term prognosis of cases confirmed with primary angiitis of the central nervous system (PACNS) by biopsy, analyze the risk factors, and provide clinical guidance for the diagnosis and treatment of the disease. METHODS Retrospective analysis was performed on 28 cases of PACNS confirmed by biopsy, and the age, gender, pathological results, course of the disease, imaging manifestations, treatment, and prognosis of the patients were analyzed and summarized. RESULTS The cohort (age 16-60 years) comprised of 16 males. The average time from the visit to diagnosis was 6 months. The first symptom was chronic headache in 18 patients. The pathological results were accompanied by demyelination in 10 cases and glial hyperplasia in 6 cases. A total of 27 patients received treatments including glucocorticoid+cyclophosphamide; of these, 3 cases of craniotomy were improved. Among the 28 patients, 15 patients improved after the treatment, 12 patients had no significant improvement, and 1 patient was deceased. Patients with a long course of the disease before diagnosis, a Karnofsky performance status (KPS) score |
| Databáze: | OpenAIRE |
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