Nickel-Catalyzed Cyanation of Aryl Thioethers
| Autor: | Delcaillau, Tristan, Woenckhaus-Alvarez, Adrian, Morandi, Bill |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Zdroj: | Organic Letters, 23 (18) |
| ISSN: | 1523-7060 1523-7052 |
| DOI: | 10.3929/ethz-b-000508239 |
| Popis: | A nickel-catalyzed cyanation of aryl thioethers using Zn(CN)2 as a cyanide source has been developed to access functionalized aryl nitriles. The ligand dcype (1,2-bis(dicyclohexylphosphino)ethane) in combination with the base KOAc (potassium acetate) is essential for achieving this transformation efficiently. This reaction involves both a C–S bond activation and a C–C bond formation. The scalability, low catalyst and reagents loadings, and high functional group tolerance have enabled both late-stage derivatization and polymer recycling, demonstrating the reaction’s utility across organic chemistry. Organic Letters, 23 (18) ISSN:1523-7060 ISSN:1523-7052 |
| Databáze: | OpenAIRE |
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